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疑似眼组织胞浆菌病黄斑病变中的HLA - B7

HLA-B7 in presumed ocular histoplasmosis maculopathy.

作者信息

Godfrey W A, Cross D E, Ziemianski M C, Sabates R

出版信息

Transplant Proc. 1979 Dec;11(4):1874-6.

PMID:531932
Abstract

Sixty-four patients that fulfill the clinical criteria of the presumed ocular histoplasmosis syndrome were typed for common histocompatibility antigens. The clinical criteria included the presence of multiple peripheral punched out choroidal atropic scars, a clear vitreous, and compatible macular disciform lesions in at least one eye. Thirty-four patients were found to have HLA-B7, which is statistically significant at the p less than 0.005 level when compared to a normal population. Though this is statistically significant, other factors must be involved, as there still remain many patients with this clinical picture who do not demonstrate a common histocompatibility antigen.

摘要

对64例符合疑似眼组织胞浆菌病综合征临床标准的患者进行了常见组织相容性抗原分型。临床标准包括至少一只眼存在多个周边凿孔状脉络膜萎缩性瘢痕、玻璃体清晰以及符合条件的黄斑盘状病变。发现34例患者具有HLA - B7,与正常人群相比,在p小于0.005水平具有统计学意义。尽管这具有统计学意义,但必然还涉及其他因素,因为仍有许多具有此临床症状的患者未表现出共同的组织相容性抗原。

相似文献

1
HLA-B7 in presumed ocular histoplasmosis maculopathy.疑似眼组织胞浆菌病黄斑病变中的HLA - B7
Transplant Proc. 1979 Dec;11(4):1874-6.
2
Association of presumed ocular histoplasmosis with HLA-B7.
Am J Ophthalmol. 1978 Jun;85(6):854-8. doi: 10.1016/s0002-9394(14)78117-6.
3
Association of presumed ocular histoplasmosis with HLA-B7 and DRw2.
Transplant Proc. 1979 Dec;11(4):1877-8.
4
Amino acid residue 67 (isoleucine) of HLA-DRB is associated with POHS.人类白细胞抗原-DRB的氨基酸残基67(异亮氨酸)与进行性眼外肌麻痹相关。
Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1725-9.
5
Association of HLA-DRw2 antigen with presumed ocular histoplasmosis.HLA - DRw2抗原与推测的眼组织胞浆菌病的关联。
Am J Ophthalmol. 1980 Jan;89(1):70-6. doi: 10.1016/0002-9394(80)90232-9.
6
The prevalence of HLA-B7 in presumed ocular histoplasmosis in patients with peripheral atrophic scars.
Am J Ophthalmol. 1978 Sep;86(3):325-8. doi: 10.1016/0002-9394(78)90233-7.
7
Presumed ocular histoplasmosis.
Trans Ophthalmol Soc U K (1962). 1981;101 (Pt 4):403-8.
8
The prevalence of HLA-B7 in presumed ocular histoplasmosis.
Am J Ophthalmol. 1978 Jun;85(6):859-61. doi: 10.1016/s0002-9394(14)78118-8.
9
MICA association with presumed ocular histoplasmosis syndrome (POHS).
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10
[Presumed ocular histoplasmosis syndrome].
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