Matthes G, Hackensellner H A, Dahlke A, Oehme P, Jentzsch K D
Z Exp Chir. 1979;12(3):188-94.
Investigations about the protective effect of the pretreatment of albino rats with different concentrations of sodium selenite in sodium chloride solution were carried out. Albino rats, serving as a control group, had only a pretreatment with sodium chloride solution. The following results were obtained: 1. An intraperitoneal application of 2 microgram sodium selenite per kg body weight over three days shows a significant increase of contractility of frozen and afterwards re-thawed fragments of heart-muscle after storage -196 degrees C. 2. The increase or decrease of the sodium selenite dose by the factor ten had no effect on the preservation of the contractility of fragments of the heart-muscle after storage -196 degrees C in comparison to the control group. 3. A differentiated observation of the injuries under frozen preservation permitted the conclusion that the pretreatment with sodium selenite for the most parts will be protective in the phase below 0 degrees.
对白化大鼠用不同浓度亚硒酸钠的氯化钠溶液进行预处理的保护作用展开了研究。作为对照组的白化大鼠仅用氯化钠溶液进行预处理。得到了以下结果：1. 连续三天腹腔注射每千克体重2微克亚硒酸钠，结果显示，在-196℃储存后再解冻的心肌片段的收缩性显著增加。2. 与对照组相比，亚硒酸钠剂量增加或减少十倍对-196℃储存后的心肌片段收缩性的保存没有影响。3. 对冷冻保存下的损伤进行的差异观察得出结论：在大部分情况下，亚硒酸钠预处理在0℃以下阶段具有保护作用。
