Shepherd M
Proc R Soc Med. 1965 Nov;58(11 Part 2):964-7. doi: 10.1177/003591576505811P205.
As a biological phenomenon the interaction between drugs may be viewed in ;explanatory' or ;empirical' terms. In clinical psychopharmacology the former is rarely possible: two examples are cited, one concerning amphetamine and reserpine, the other desmethyl-imipramine and tetrabenazine. Among centrally acting substances, empirical studies of the interaction between alcohol and the barbiturates have been pursued intensively by several methods in clinic and laboratory. Both general considerations and recent work on the effects of amphetamine-barbiturate combinations suggest caution in the medical use of mixtures of psychotropic drugs. Adverse reactions caused by interaction between psychotropic drugs and other substances have still to be studied systematically as a potential hazard.
作为一种生物学现象，药物之间的相互作用可以从“解释性”或“经验性”角度来看待。在临床精神药理学中，前者很少可行：文中列举了两个例子，一个涉及苯丙胺和利血平，另一个涉及去甲丙咪嗪和丁苯那嗪。在中枢作用物质中，通过临床和实验室的几种方法对酒精与巴比妥类药物之间的相互作用进行了深入的经验性研究。一般性考虑以及近期关于苯丙胺 - 巴比妥类药物组合效果的研究均表明，在精神药物混合使用的医学应用中应谨慎。精神药物与其他物质相互作用引起的不良反应作为一种潜在危害仍有待系统研究。
