乙醇和硫酸苯丙胺对人体受试者行为表现的联合作用。
The combined effects of ethanol and amphetamine sulfate on performance of human subjects.
作者信息
Wilson L, Taylor J D, Nash C W, Cameron D F
出版信息
Can Med Assoc J. 1966 Mar 5;94(10):478-84.
The combined effects of ethanol and amphetamine on the performance of selected tests were evaluated. No differences were shown between the effects of ethanol-amphetamine and ethanol-lactose on the performance of balance, skipping, Minnesota manipulation, Purdue peg board, Maudsley Personality Inventory, pursuit rotor or digit span tests; but ethanol plus amphetamine produced less impairment of performance of coding, mental addition, and trail making tests than did ethanol plus a placebo. Ethanol increased the errors in performance of the Wonderlic Personnel Test, but the simultaneous administration of amphetamine did not reduce this effect. Conversely, amphetamine reduced the test-retest reliability of the Wonderlic Personnel Test, but alcohol appeared to counteract this effect of amphetamine. These experiments indicate that, when ethanol and amphetamine are used together, each drug modifies some of the effects produced by the other in a manner that cannot be predicted on the assumption that a depressant versus stimulant competition is operative.
评估了乙醇和苯丙胺对所选测试表现的联合影响。乙醇-苯丙胺组与乙醇-乳糖组在平衡、跳绳、明尼苏达操作、普渡钉板、莫兹利人格量表、追踪转子或数字广度测试的表现上未显示出差异；但与乙醇加安慰剂相比，乙醇加苯丙胺对编码、心算和连线测试表现的损害更小。乙醇增加了旺德利克人员测试表现中的错误，但同时给予苯丙胺并未减少这种影响。相反，苯丙胺降低了旺德利克人员测试的重测信度，但酒精似乎抵消了苯丙胺的这种影响。这些实验表明，当乙醇和苯丙胺一起使用时，每种药物都会以一种无法基于抑制与兴奋竞争起作用这一假设来预测的方式改变另一种药物产生的某些影响。
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