Judd L L, Huey L Y
Am J Psychiatry. 1984 Dec;141(12):1517-21. doi: 10.1176/ajp.141.12.1517.
Thirty-five detoxified alcoholics given lithium in a placebo-controlled, double-blind study reported less intoxication, a decrease in the desire to continue drinking, and less cognitive dysfunction when challenged by standardized doses of ethanol. Lithium also appeared to antagonize the ethanol-induced decrement in cognitive and perceptual motor performance. No differential lithium effect was noted when alcoholics were divided by diagnoses of affective disorder versus no affective disorder. The authors suggest that, in addition to mood normalization, lithium's capacity to directly affect ethanol intoxication may help explain its potential therapeutic efficacy in alcoholism, providing further confirmatory evidence that lithium may be useful in the treatment of alcoholism.
在一项安慰剂对照的双盲研究中，35名接受锂治疗的戒酒者报告称，在接受标准化剂量乙醇挑战时，中毒程度减轻，继续饮酒的欲望降低，认知功能障碍也有所减轻。锂似乎还能拮抗乙醇引起的认知和感知运动能力下降。当根据是否患有情感障碍对酗酒者进行分类时，未发现锂有差异效应。作者认为，除了使情绪正常化外，锂直接影响乙醇中毒的能力可能有助于解释其在酒精中毒治疗中的潜在疗效，这进一步证实了锂可能对治疗酒精中毒有用。
