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雪旺细胞在体外的搏动性和形成髓鞘的活性。

Pulsatile and myelin-forming activities of Schwann cells in vitro.

作者信息

Ernyei S, Young M R

出版信息

J Physiol. 1966 Mar;183(2):469-80. doi: 10.1113/jphysiol.1966.sp007877.

DOI:10.1113/jphysiol.1966.sp007877
PMID:5328990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1357589/
Abstract
  1. Sympathetic and dorsal root ganglia from young mice and new-born rats were cultured in vitro. The activity of the outgrowing Schwann cells was studied with time-lapse photography.2. Schwann cells exhibited a pulsatile activity with a contraction rate varying from 1 to 12 min. The occurrence of pulsations depended on the mode of attachment of cells to their surroundings.3. Fibres of various materials were introduced into the cultures in an attempt to simulate conditions obtaining in vivo. Schwann cells attached themselves to these fibres and rotated about them depositing myelin. Polarized light and histochemical studies showed that myelin was formed as early as four days in vitro.4. The possible significance of the behaviour of Schwann cells in vitro is discussed.
摘要

  1. 取幼年小鼠和新生大鼠的交感神经节和背根神经节进行体外培养。采用延时摄影技术研究生长中的施万细胞的活性。

  2. 施万细胞表现出搏动性活动，收缩频率为1至12分钟不等。搏动的出现取决于细胞与周围环境的附着方式。

  3. 将各种材料的纤维引入培养物中，试图模拟体内的情况。施万细胞附着于这些纤维并围绕它们旋转，沉积髓磷脂。偏振光和组织化学研究表明，体外培养四天时就已形成髓磷脂。

  4. 讨论了施万细胞在体外行为的可能意义。

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