Reyns P R, Romney D, Desser K B, Benchimol A
Angiology. 1979 Dec;30(12):850-5. doi: 10.1177/000331977903001209.
Prazosin was administered orally at a maximal dose of 2 mg every 6 hours to 4 patients with congestive heart failure (CHF) who had not received either digitalis or diuretics for 72 hours before therapy. Three of the 4 patients had hypertensive and arteriosclerotic heart disease. Hemodynamic monitoring indicated a significant reduction of preload and afterload with a concomitant rise in the cardiac index. We concluded that isolated low-dose oral prazosin has salutary effects on indices of hemodynamic function in selected patients.
对4例充血性心力衰竭（CHF）患者口服哌唑嗪，最大剂量为每6小时2mg，这些患者在治疗前72小时未接受洋地黄或利尿剂治疗。4例患者中有3例患有高血压和动脉硬化性心脏病。血流动力学监测表明，前负荷和后负荷显著降低，同时心脏指数升高。我们得出结论，单独使用低剂量口服哌唑嗪对选定患者的血流动力学功能指标有有益作用。
