Manac'h Y, Narcy P, Gandon J, Morice P, Cornec C
Ann Otolaryngol Chir Cervicofac. 1979 Dec;96(12):889-94.
This study of reinnervation of the larynx results from the research for a functional method of treatment for laryngeal paralysis of peripheral origin. The physiological reality of reinnervation of a denervated muscle by a nerve other than that anatomically destined for it, or "neurotisation", is now an established fact. This experimental study in 12 dogs consisted of neurotisation of a posterior crico-thyroid muscle, denervated by section of the recurrent laryngeal nerve, by implantation of a graft of sub-hyoid muscle with a nerve pedicle. Only one positive result at six months was seen. 8 failures could be explained by the absence of ventilatory difficulty necessary for the sub-hyoid muscles to be brought into action, and the other 3 failures two months after the operation by muscular fibrosis of the graft before neurotisation could occur. Physiology and the experience of other teams justify the continuation of this study.
这项关于喉再支配的研究源于对周围性喉麻痹功能性治疗方法的探索。由并非解剖学上注定支配它的神经对失神经肌肉进行再支配,即“神经移植”,其生理现实如今已是既定事实。这项对12只狗进行的实验研究包括,通过植入带神经蒂的舌骨下肌移植物,对因喉返神经切断而失神经的环甲后肌进行神经移植。6个月时仅出现1例阳性结果。8例失败可归因于缺乏使舌骨下肌发挥作用所需的通气困难,另外3例在术后两个月失败是因为在神经移植发生之前移植物出现了肌肉纤维化。生理学及其他团队的经验证明这项研究有继续进行的必要。