Rice-Wray E, Becerra C, Esquivel J, Maqueo M
Can Med Assoc J. 1966 Nov 12;95(20):1024-30.
Contraception with lynestrenol-mestranol (Lyndiol) was studied in 332 Mexican women during a period of two and one-half years. Side effects were minimal or transient. No pregnancies occurred in those who took the medication according to instructions. The women were followed with yearly pelvic examinations and Papanicolaou smears, serial endometrial biopsies and extensive studies of blood, liver and glandular function. Complete ophthalmological studies were done on 30 patients. No clinical or laboratory evidence of harmful effects could be demonstrated. Return to ovulation (using pregnanediol excretion and endometrial biopsies as parameters) occurred in all of 22 women studied in the first three post-treatment cycles. Eight posttreatment pregnancies and the resulting offspring were normal. The first post-treatment cycle, as with other oral contraceptives, was unpredictable and tended to be prolonged. It varied in length from 22 to 60 days.
在两年半的时间里，对332名墨西哥女性使用炔雌醇甲醚（林迪欧）进行避孕研究。副作用轻微或短暂。按说明服药者无妊娠发生。对这些女性进行了每年一次的盆腔检查、巴氏涂片检查、系列子宫内膜活检以及血液、肝脏和腺体功能的广泛研究。对30名患者进行了全面的眼科检查。未发现有害影响的临床或实验室证据。在治疗后的前三个周期研究的22名女性中，所有人（以孕二醇排泄和子宫内膜活检为参数）均恢复排卵。8例治疗后妊娠及所产后代均正常。与其他口服避孕药一样，治疗后的第一个周期不可预测，且往往延长。其长度从22天到60天不等。
