母亲使用萘普生治疗后早产儿的持续性肺动脉高压和异常前列腺素E水平。
Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen.
作者信息
Wilkinson A R, Aynsley-Green A, Mitchell M D
出版信息
Arch Dis Child. 1979 Dec;54(12):942-5. doi: 10.1136/adc.54.12.942.
Abstract
Twins and a singleton were born at 30 weeks' gestation although naproxen (d-2 (6'methoxy-2-naphthyl) propionic acid) had been given to the mothers in an attempt to delay parturition. Inhibition of prostaglandin synthesis was shown by very low plasma concentrations of prostaglandin E and the ductus arteriosus remained closed despite signs of pulmonary hypertension with severe hypoxaemia. Abnormalities in blood clotting, renal function, and bilirubin metabolism were also found and one infant died. Further studies of the benefits and risks of the inhibition of prostaglandin synthesis are required before this treatment of preterm labour is accepted.
摘要
尽管已给母亲们使用萘普生（d - 2 -（6'-甲氧基 - 2 - 萘基）丙酸）以试图延迟分娩，但仍有一对双胞胎和一个单胎婴儿在妊娠30周时出生。血浆中前列腺素E的浓度极低，表明前列腺素合成受到抑制，尽管存在肺动脉高压伴严重低氧血症的迹象，但动脉导管仍保持闭合。还发现了凝血、肾功能和胆红素代谢方面的异常，一名婴儿死亡。在这种早产治疗方法被接受之前，需要对抑制前列腺素合成的益处和风险进行进一步研究。
相似文献
1
Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen.母亲使用萘普生治疗后早产儿的持续性肺动脉高压和异常前列腺素E水平。
Arch Dis Child. 1979 Dec;54(12):942-5. doi: 10.1136/adc.54.12.942.
2
Prostaglandin synthesis inhibition in persistent pulmonary hypertension of the newborn.
Clin Perinatol. 1984 Oct;11(3):581-9.
3
Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates.两例早产儿应用 L-赖氨酸布洛芬治疗重度肺动脉高压。
Pediatrics. 2012 May;129(5):e1360-3. doi: 10.1542/peds.2011-0117. Epub 2012 Apr 9.
4
Preterm parturition. Prostaglandin synthetase inhibitors.
Semin Perinatol. 1981 Jul;5(3):274-87.
5
[Maternal treatment with indomethacin and severe neonatal pulmonary hypertension (author's transl)].
Arch Fr Pediatr. 1981 Apr;38(4):261-5.
6
Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn: a case report.足月新生儿母亲服用萘普生后持续性肺动脉高压：一例报告
Am J Perinatol. 2000;17(2):69-71. doi: 10.1055/s-2000-9271.
7
Neonatal complications after the administration of indomethacin for preterm labor.吲哚美辛用于早产治疗后的新生儿并发症。
N Engl J Med. 1993 Nov 25;329(22):1602-7. doi: 10.1056/NEJM199311253292202.
8
Prostaglandin F and E levels during endotoxin-induced pulmonary hypertension in calves.犊牛内毒素诱导的肺动脉高压期间前列腺素F和E水平
Am J Physiol. 1975 May;228(5):1479-82. doi: 10.1152/ajplegacy.1975.228.5.1479.
9
Plasma concentrations of prostaglandins during late human pregnancy: influence of normal and preterm labor.人类妊娠晚期血浆中前列腺素的浓度：正常分娩和早产的影响。
J Clin Endocrinol Metab. 1978 Jun;46(6):947-51. doi: 10.1210/jcem-46-6-947.
10
Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn.
Am J Obstet Gynecol. 1976 Oct 15;126(4):467-9. doi: 10.1016/0002-9378(76)90640-2.
引用本文的文献
1
Hematologic Complications of Pregnancy.妊娠的血液学并发症
Eur J Haematol. 2025 Apr;114(4):596-614. doi: 10.1111/ejh.14372. Epub 2025 Jan 10.
2
Society for Maternal-Fetal Medicine Consult Series #68: Sickle cell disease in pregnancy.母胎医学协会咨询系列#68：妊娠期镰状细胞病
Am J Obstet Gynecol. 2024 Feb;230(2):B17-B40. doi: 10.1016/j.ajog.2023.10.031. Epub 2023 Oct 21.
3
Risk estimation of fetal adverse effects after short-term second trimester exposure to non-steroidal anti-inflammatory drugs: a literature review.非甾体类抗炎药短期暴露于妊娠中期对胎儿不良影响的风险评估：文献综述。
Eur J Clin Pharmacol. 2019 Oct;75(10):1347-1353. doi: 10.1007/s00228-019-02712-2. Epub 2019 Jul 4.
4
Prenatal effects of maternal consumption of polyphenol-rich foods in late pregnancy upon fetal ductus arteriosus.孕期晚期母亲食用富含多酚的食物对胎儿动脉导管的产前影响。
Birth Defects Res C Embryo Today. 2013 Dec;99(4):256-74. doi: 10.1002/bdrc.21051.
5
A single dose of celecoxib 200 mg improves postoperative analgesia provided via patient-controlled epidural technique after caesarean section.单次服用塞来昔布 200 毫克可改善剖宫产术后患者自控硬膜外镇痛效果。
Arch Med Sci. 2013 Oct 31;9(5):877-82. doi: 10.5114/aoms.2012.31253. Epub 2012 Oct 16.
6
Nonsteroidal antiinflammatory drugs in late pregnancy and persistent pulmonary hypertension of the newborn.非甾体类抗炎药在妊娠晚期与新生儿持续性肺动脉高压。
Pediatrics. 2013 Jan;131(1):79-87. doi: 10.1542/peds.2012-0496. Epub 2012 Dec 3.
7
Treatment of inflammatory rheumatic disorders in pregnancy: what are the safest treatment options?妊娠期炎性风湿性疾病的治疗：最安全的治疗选择有哪些？
Drug Saf. 1998 Nov;19(5):389-410. doi: 10.2165/00002018-199819050-00006.
8
Drug induced closure of patent ductus arteriosus.药物诱导动脉导管未闭闭合
Heart. 1996 Nov;76(5):384-5. doi: 10.1136/hrt.76.5.384.
9
Optimisation of antirheumatic drug treatment in pregnancy.孕期抗风湿药物治疗的优化
Clin Pharmacokinet. 1994 Dec;27(6):486-503. doi: 10.2165/00003088-199427060-00006.
10
Relaxation of human isolated pulmonary arteries by prostacyclin (PGI2).前列环素（PGI2）对人离体肺动脉的舒张作用。
Lung. 1983;161(2):123-30. doi: 10.1007/BF02713850.
本文引用的文献
1
Inhibition of human premature labor by indomethacin.
Obstet Gynecol. 1974 Dec;44(6):787-92.
2
Premature labor and indomethacin.早产与吲哚美辛
Prostaglandins. 1975 Sep;10(3):515-26. doi: 10.1016/0090-6980(75)90132-x.
3
Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn.
Am J Obstet Gynecol. 1976 Oct 15;126(4):467-9. doi: 10.1016/0002-9378(76)90640-2.
4
Effects of acetylsalicylic acid on the ductus arteriosus and circulation in fetal lambs in utero.
Circ Res. 1976 May;38(5):418-22. doi: 10.1161/01.res.38.5.418.
5
Plasma prostaglandin levels during early neonatal life following term and pre-term delivery.足月儿和早产儿出生后早期新生儿期的血浆前列腺素水平。
Prostaglandins. 1978 Aug;16(2):319-26. doi: 10.1016/0090-6980(78)90033-3.
6
Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome.母亲使用吲哚美辛治疗与胎儿循环综合征持续存在的关系。
J Pediatr. 1978 Mar;92(3):484. doi: 10.1016/s0022-3476(78)80454-5.
7
Constriction of the fetal ductus arteriosus after administration of indomethacin to the pregnant ewe.给怀孕母羊注射吲哚美辛后胎儿动脉导管的收缩。
J Pediatr. 1979 Apr;94(4):647-50. doi: 10.1016/s0022-3476(79)80043-8.
8
Pulmonary vascular responses to prostaglandins and prostaglandin synthetase inhibitors in perinatal goats.围产期山羊肺血管对前列腺素和前列腺素合成酶抑制剂的反应
Adv Prostaglandin Thromboxane Res. 1978;4:249-56.
9
Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors.
J Pediatr. 1978 Mar;92(3):478-83. doi: 10.1016/s0022-3476(78)80453-3.
Zotero 插件