Kendall M W
Arch Environ Contam Toxicol. 1979;8(1):25-41. doi: 10.1007/BF01055138.
The fire-ant poison, Mirex, was administered via stomach tube (dosage 200 mg/kg) to 50 adult Mai-Wistar male rats and the resultant histopathologic lesions produced in their livers after six days post-intubation are described. Light (LM) and electron microscopic (EM) technques revealed cellular and subcellular alterations in response to this sublethal dosage. Pathologic lipid accumulations occurred in Mirex-exposed rats and this fat appeared in a distinctive periportal zonation pattern. Additional lesions were detected in centrolobular zones with the EM and included severe glycogen depletion, altered regularity in the architecture of rough or granular endoplasmic reticulum (GER), dilated GER cisternae, free ribosomes, and proliferation of smooth endoplasmic reticulum. Periportal hepatocytes exhibited apparent reduction in numbers of cytoplasmic organelles and development of many, large lipid-containing vacuoles. Myelin figures were sometimes associated with developing lipid (liposomes), suggesting a contribution of myelin membranes to the developing lipid droplets or vice versa. Biochemical studies revealed that glycogen levels dropped markedly, lipid content greatly increased, and protein/DNA and RNA/DNA values decreased.
通过胃管给50只成年雄性麦-威斯塔大鼠注射火蚁毒药灭蚁灵（剂量为200毫克/千克），并描述插管后六天其肝脏中产生的组织病理学损伤。光学显微镜（LM）和电子显微镜（EM）技术揭示了对这种亚致死剂量的细胞和亚细胞改变。在接触灭蚁灵的大鼠中出现了病理性脂质蓄积，且这种脂肪以独特的门周带模式出现。用电子显微镜在小叶中心区检测到其他损伤，包括严重的糖原耗竭、粗面或颗粒内质网（GER）结构的规则性改变、GER池扩张、游离核糖体以及滑面内质网增生。门周肝细胞的细胞质细胞器数量明显减少，出现许多大的含脂空泡。髓鞘样结构有时与正在形成的脂质（脂质体）相关，提示髓鞘膜对脂质小滴的形成有贡献，反之亦然。生化研究表明，糖原水平显著下降，脂质含量大幅增加，蛋白质/DNA和RNA/DNA值降低。
