Ota K, Era K, Suwa S, Kaneko I, Aida K, Agishi T
Artif Organs. 1979 Nov;3(4):350-3. doi: 10.1111/j.1525-1594.1979.tb01076.x.
A new method for urea removal using a gas membrane is introduced along with some preliminary results. The membrane used was expanded polytetrafluoroethylene (E-PTFE) which is highly permeable to gaseous substances, while at the same time it is highly resistant to water permeation. In in vitro experiments using 10 mmol/L ammonia solution it was revealed that the single-pass reduction rate was approximately 95% at 30 degrees C at a flow rate of 200 ml/min. In animal experiments using four dogs, the extraction rate of urea was 40.4 +/- 4.4% after four hours of dialysis using 5 L dialysate. However, elevation of blood ammonia was observed in all dogs tested. Removal of ammonia by means of a gas membrane is considered to be feasible and has the possibility of being used for maintenance hemodialysis in combination with urease and charcoal.
介绍了一种使用气体膜去除尿素的新方法以及一些初步结果。所使用的膜是膨体聚四氟乙烯（E-PTFE），它对气态物质具有高渗透性，同时对水渗透具有高度抗性。在使用10 mmol/L氨溶液的体外实验中，发现在30℃、流速为200 ml/min时单程还原率约为95%。在使用四只狗的动物实验中，使用5 L透析液透析4小时后，尿素提取率为40.4±4.4%。然而，在所有受试犬中均观察到血氨升高。通过气体膜去除氨被认为是可行的，并且有可能与脲酶和木炭联合用于维持性血液透析。
