丙胺太林与丙咪嗪对膀胱及唾液腺功能影响的比较。

A comparison between propantheline and imipramine on bladder and salivary gland function.

作者信息

Tulloch A G, Creed K E

出版信息

Br J Urol. 1979 Oct;51(5):359-62. doi: 10.1111/j.1464-410x.1979.tb02886.x.

DOI:10.1111/j.1464-410x.1979.tb02886.x

Abstract

The effects of propantheline and imipramine on detrusor function and salivary gland secretion were studied in the dog. Both drugs caused a decrease in the rise of intravesical pressure following pelvic nerve stimulation in the anaesthetised dog. Propantheline had a profound effect on the salivary gland, whereas imipramine had very little effect on the volume of saliva produced after electrical stimulation of the chorda tympani. This suggests that the action of imipramine on the bladder is not anticholinergic. The significance for treatment of detrusor dysfunction is discussed.

摘要

研究了丙胺太林和丙咪嗪对犬逼尿肌功能及唾液腺分泌的影响。在麻醉犬中，两种药物均使盆神经刺激后膀胱内压的升高幅度降低。丙胺太林对唾液腺有显著作用，而丙咪嗪对鼓索神经电刺激后产生的唾液量几乎没有影响。这表明丙咪嗪对膀胱的作用并非抗胆碱能作用。文中讨论了其对逼尿肌功能障碍治疗的意义。