Br J Urol. 1979 Oct;51(5):382-9. doi: 10.1111/j.1464-410x.1979.tb02891.x.
Plasma concentrations of testosterone, oestradiol-17 beta, luteinising hormone (LH), follicle stimulating hormone (FSH), prolactin and growth hormone (GH) were measured in patients with histologically proven prostatic cancer, before any form of therapy was given for this disease. Patients were categorised according to UICC classification. No systemic change in the group means of any of these hormones was associated with the progression of the disease from the T0 to the T4 stage. When multivariate analysis was applied to the combined intraprostatic (T0 + T1 + T2) and extraprostatic (T3 + T4) tumour category in patients without clinically evident metastases (M0) a discrimination was observed, GH substantially contributing to the separation of the 2 groups. When plasma hormone data from patients classified as M0 (without metastases) were compared with M1 patients (with metastases), mean GH values were significantly larger (P less than 0.02) in patients with metastases. GH was also a major contributory factor to the discrimination between the M0 and M1 groups, using multivariate analysis. Testosterone group means for M0 versus M1 were also significantly different (P less than 0.02).
在组织学确诊为前列腺癌的患者中，于对该疾病进行任何形式的治疗之前，测定了睾酮、雌二醇 - 17β、黄体生成素（LH）、卵泡刺激素（FSH）、催乳素和生长激素（GH）的血浆浓度。患者根据国际抗癌联盟（UICC）分类进行分组。这些激素中任何一种在各组中的均值均未发现与疾病从T0期进展至T4期存在系统性关联。当对无临床明显转移（M0）的患者，将前列腺内（T0 + T1 + T2）和前列腺外（T3 + T4）肿瘤类别合并进行多因素分析时，发现了一种区分，其中GH对两组的区分起了很大作用。当将分类为M0（无转移）患者的血浆激素数据与M1患者（有转移）的数据进行比较时，有转移患者的GH均值显著更高（P < 0.02）。使用多因素分析时，GH也是区分M0和M1组的主要因素。M0与M1的睾酮组均值也存在显著差异（P < 0.02）。
