喹吖因（阿的平）：作用方式。
Quinacrine (atebrin): mode of action.
作者信息
Ciak J, Hahn F E
出版信息
Science. 1967 May 5;156(3775):655-6. doi: 10.1126/science.156.3775.655.
PMID:5337177
Abstract
Quinacrine at a concentration of 8 x 10(-4) mole per liter is bactericidal for Escherichia coli, blocks DNA synthesis, and inhibits the syntheses of RNA and protein strongly. At a concentration of 2x 10(-4) mole per liter, the drug is bacteriostatic, the syntheses of protein and DNA (but not that of RNA) are partially inhibited, and the bacteria grow into giant filaments. Impairment of DNA replication is proposed as the mode of action of quinacrine.
摘要
每升浓度为8×10⁻⁴摩尔的阿的平对大肠杆菌具有杀菌作用，可阻断DNA合成，并强烈抑制RNA和蛋白质的合成。在每升浓度为2×10⁻⁴摩尔时，该药物具有抑菌作用，蛋白质和DNA（但不包括RNA）的合成受到部分抑制，细菌长成巨大的丝状体。阿的平的作用方式被认为是损害DNA复制。
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