Verbina N M, Viktorova L S
Mikrobiologiia. 1982 Jul-Aug;51(4):565-9.
Sulfochloranthine was shown to be bacteriostatic for Escherichia coli B cells grown in a chemically defined medium at a concentration of 0.002%, sublethal at a concentration of 0.005%, and lethal at 0.01% (0.000312, 0.00078 and 0.00156% of active chlorine, respectively). Protein synthesis by E. coli B cells was noticeably inhibited when the concentration of the preparation was 0.002%, and stopped completely at a 0.01% concentration of the preparation. Biosynthesis of nucleic acids, in particular DNA, was inhibited to a lesser extent. The bacteriostatic concentration of the preparation had virtually no effect on DNA biosynthesis, but inhibited RNA biosynthesis by 50%. Sulfochloranthine used at sublethal doses inhibited synthesis of both DNA and RNA by 75%; DNA and RNA biosynthesis ceased at the lethal concentration of the preparation.
在化学限定培养基中培养的大肠杆菌B细胞，当磺氯兰浓度为0.002%时对其有抑菌作用，浓度为0.005%时为亚致死剂量，浓度为0.01%时（分别为有效氯的0.000312%、0.00078%和0.00156%）则具有致死作用。当制剂浓度为0.002%时，大肠杆菌B细胞的蛋白质合成受到显著抑制，而制剂浓度为0.01%时则完全停止。核酸的生物合成，特别是DNA的生物合成，受到的抑制程度较小。该制剂的抑菌浓度实际上对DNA生物合成没有影响，但可使RNA生物合成受到50%的抑制。亚致死剂量的磺氯兰可使DNA和RNA的合成均受到75%的抑制；在制剂的致死浓度下，DNA和RNA的生物合成均停止。
