Passouant P, Besset A, Descomps B, Bonardet A, Billiard M, Nègre C
Nouv Presse Med. 1979 Oct 22;8(40):3237-42.
Secretions of GH and of PRL studied over a period of 24 hours in 6 untreated Parkinson's patients showed slight changes. The normal secretion of PRL in the female shows no nocturnal increase in the male. The secretion of GH linked to sleep is identified in the male and not in the female. These variations related to sex are interpreted as an increase in those normally found in the adult and facilitated by age. Bromocriptine given continuously at a dose of 10 to 20 mg/day for periods of 20 days to 6 months, results in suppression or a marked decrease in the 24-hour secretion of PRL. It has virtually no effect upon the secretion of GH. These results show that the dopaminergic regulation of PRL is preserved in Parkinson's disease.
在6名未经治疗的帕金森病患者中，对生长激素（GH）和催乳素（PRL）进行了24小时的分泌研究，结果显示有轻微变化。女性PRL的正常分泌在男性中无夜间增加。与睡眠相关的GH分泌在男性中可检测到，而在女性中则不然。这些与性别相关的差异被解释为成人中常见的增加，并随着年龄增长而加剧。以10至20毫克/天的剂量持续给予溴隐亭20天至6个月，可导致PRL的24小时分泌受到抑制或显著减少。它对GH的分泌几乎没有影响。这些结果表明，帕金森病中PRL的多巴胺能调节功能得以保留。
