Jaeger A, Rodier L, Tempe J D, Lutun P, Mayer S, Mantz J M
Nouv Presse Med. 1979 Nov 19;8(45):3741-3.
The authors report the case of a 25-year-old patient who during discontinuous treatment with a venotropic agent containing catechines suffered from intravascular haemolysis, thrombocytopaenia and acute renal failure, the course of which was favourable with treatment by haemodialysis. Renal biopsy revealed lesions of acute tubulonephritis with a slight interstitial reaction but without immune deposits. The demonstration in the serum and on the red cells of the patient of anti-catechine antibodies confirmed the immunoallergic nature of the haemolysis. The existence of crossed allergy with another venotropic agent, leucocyanide, led to suspicion of the localisation of the antigenic site on the 3-4 dihydroxyphenyl portion of the catechine molecule.
作者报告了一例25岁患者的病例，该患者在间断使用含儿茶素的静脉营养药物治疗期间，出现血管内溶血、血小板减少和急性肾衰竭，经血液透析治疗后病情好转。肾活检显示急性肾小管肾炎病变，伴有轻微间质反应，但无免疫沉积物。在患者血清和红细胞上检测到抗儿茶素抗体，证实了溶血的免疫过敏性本质。与另一种静脉营养药物白氰化物存在交叉过敏，这使得人们怀疑抗原位点位于儿茶素分子的3,4 - 二羟基苯基部分。
