水杨酸的消除动力学及龙胆酸的形成
The kinetics of elimination of salicylic acid and the formation of gentisic acid.
作者信息
Boreham D R, Martin B K
出版信息
Br J Pharmacol. 1969 Sep;37(1):294-300. doi: 10.1111/j.1476-5381.1969.tb09546.x.
Abstract
- A method for the estimation of gentisic acid in urine has been devised which is based on thin-layer chromatography and fluorimetry.2. In man the urinary excretion of gentisic acid accounted for 0.6% of a 0.32 g dose of aspirin and 1.1% of a 1.28 g dose. The increase in the percentage of the dose excreted as gentisic acid provides further evidence that the elimination of salicylic acid cannot be entirely described by first order kinetics.3. Equations are presented which describe the amount of gentisic acid formed from various doses of salicylic acid in a model system, when elimination proceeds partly by simultaneous first order and zero order kinetics. The close agreement of the experimental and theoretical results indicates that the model provides an acceptable interpretation of salicylic acid elimination in man.
摘要
已设计出一种基于薄层色谱法和荧光分析法的尿中龙胆酸估算方法。
在人体中，龙胆酸的尿排泄量在0.32克阿司匹林剂量中占0.6%，在1.28克剂量中占1.1%。以龙胆酸形式排泄的剂量百分比增加，进一步证明水杨酸的消除不能完全用一级动力学来描述。
给出了一些方程式，这些方程式描述了在一个模型系统中，当消除部分通过同时进行的一级动力学和零级动力学进行时，不同剂量水杨酸形成的龙胆酸量。实验结果与理论结果的密切吻合表明，该模型为人体中水杨酸的消除提供了可接受的解释。
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本文引用的文献
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The determination and metabolism of gentisic acid.龙胆酸的测定与代谢
J Biol Chem. 1951 Sep;192(1):105-14.
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The metabolism of C14 carboxyl salicylic acid in the dog and in man.狗和人体内C14羧基水杨酸的代谢
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A KINETIC STUDY OF THE ELIMINATION OF SALICYLATE IN MAN.人体中水杨酸盐消除的动力学研究。
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DRUG ELIMINATION BY SIMULTANEOUS FIRST-ORDER AND ZERO-ORDER PROCESSES.通过一级和零级过程同时进行的药物消除
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Fate of gentisic acid in man as influenced by alkalinization and acidification.
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