• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Folate reductase and specific dihydrofolate reductase activities of the amethopterin-sensitive Streptococcus faecium var. durans.氨甲蝶呤敏感的粪肠球菌变种耐久肠球菌的叶酸还原酶和特异性二氢叶酸还原酶活性。
J Bacteriol. 1969 Oct;100(1):533-4. doi: 10.1128/jb.100.1.533-534.1969.
2
Dihydrofolate reductase activity in strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin.粪肠球菌耐久亚种对甲喹酮和氨甲蝶呤耐药菌株中的二氢叶酸还原酶活性
J Bacteriol. 1972 Apr;110(1):139-45. doi: 10.1128/jb.110.1.139-145.1972.
3
Folate reductase and specific dihydrofolate reductase of the amethopterin-sensitive Streptococcus faecium var. durans.氨甲蝶呤敏感的粪链球菌变种耐久链球菌的叶酸还原酶和特异性二氢叶酸还原酶。
Biochemistry. 1969 Mar;8(3):960-7. doi: 10.1021/bi00831a029.
4
Metabolic control of synthesis of the different forms of dihydrofolate reductase of the amethopterin-resistant Streptococcus faecium var. durans A k .氨甲蝶呤抗性粪肠球菌变种耐久肠球菌A k不同形式二氢叶酸还原酶合成的代谢控制
Arch Biochem Biophys. 1972 Nov;153(1):16-25. doi: 10.1016/0003-9861(72)90415-8.
5
Dihydrofolate reductase of Streptococcus faicium. II. Purification and some properties of two dihydrofolate reductases from the amethopterin-resistant mutant Streptococcus faecium var. Durans strain A.粪肠球菌的二氢叶酸还原酶。II. 来自耐氨甲蝶呤突变型粪肠球菌变种杜兰菌株A的两种二氢叶酸还原酶的纯化及一些性质
J Biol Chem. 1968 Sep 25;243(18):4722-31.
6
Folate reductase of the amethopterin-resistant Streptococcus faecium var. durans-Ak. I. Inhibition by amethopterin and methasquin, a new quinazoline antifolate.耐氨甲蝶呤的粪肠球菌变种杜兰肠球菌-Ak的叶酸还原酶。I. 氨甲蝶呤和甲喹酮（一种新型喹唑啉抗叶酸剂）的抑制作用。
Mol Pharmacol. 1970 Jul;6(4):323-34.
7
Purification and properties of dihydrofolate reductase from an amethopterin-resistant strain of Streptococcus faecium.来自耐氨甲蝶呤粪肠球菌菌株的二氢叶酸还原酶的纯化及性质
Biochemistry. 1972 Apr 11;11(8):1528-34. doi: 10.1021/bi00758a030.
8
Amino-acid sequence of dihydrofolate reductase from a methotrexate-resistant mutant of Streptococcus faecium and identification of methionine residues at the inhibitor binding site.来自粪肠球菌甲氨蝶呤抗性突变体的二氢叶酸还原酶的氨基酸序列以及抑制剂结合位点甲硫氨酸残基的鉴定。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3001-5. doi: 10.1073/pnas.71.8.3001.
9
Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.对乙胺嘧啶、氯胍三嗪、甲氧苄啶和氨甲蝶呤耐药的屎肠球菌菌株中的二氢叶酸还原酶和胸苷酸合成酶
Arch Biochem Biophys. 1972 Jan;148(1):1-9. doi: 10.1016/0003-9861(72)90108-7.
10
The structure of dihydrofolate reductase. I. Inactivation of bacterial dihydrofolate reductase concomitant with modification of a methionine residue at the active site.二氢叶酸还原酶的结构。I. 细菌二氢叶酸还原酶的失活与活性位点甲硫氨酸残基的修饰相伴发生。
J Biol Chem. 1975 Feb 25;250(4):1580-7.

引用本文的文献

1
Interactions between inhibitors of dihydrofolate reductase.二氢叶酸还原酶抑制剂之间的相互作用。
Biochem J. 1989 Mar 1;258(2):335-42. doi: 10.1042/bj2580335.
2
Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei.来自耐甲氨蝶呤干酪乳杆菌菌株的二氢叶酸还原酶的大规模纯化及特性鉴定
Biochem J. 1976 Sep 1;157(3):559-71. doi: 10.1042/bj1570559.

本文引用的文献

1
THE GROUP D STREPTOCOCCI.D群链球菌
Bacteriol Rev. 1964 Sep;28(3):330-66. doi: 10.1128/br.28.3.330-366.1964.
2
PHYSIOLOGY OF THE ENTEROCOCCI AS RELATED TO THEIR TAXONOMY.与肠球菌分类学相关的肠球菌生理学
J Bacteriol. 1963 Dec;86(6):1275-82. doi: 10.1128/jb.86.6.1275-1282.1963.
3
Metabolism of resistant mutants of Streptococcus faecalis. I. Isolation and characterization of the mutants.粪链球菌抗性突变体的代谢。I. 突变体的分离与特性鉴定。
Cancer Res. 1958 Feb;18(2):214-9.
4
Strain variation within Streptococcus faecium var. durans.屎肠球菌耐久亚种内的菌株变异
J Bacteriol. 1966 Aug;92(2):516-7. doi: 10.1128/jb.92.2.516-517.1966.
5
Folate reductase and specific dihydrofolate reductase of the amethopterin-sensitive Streptococcus faecium var. durans.氨甲蝶呤敏感的粪链球菌变种耐久链球菌的叶酸还原酶和特异性二氢叶酸还原酶。
Biochemistry. 1969 Mar;8(3):960-7. doi: 10.1021/bi00831a029.
6
Separation of folic acid reductase from Streptococcus faecium (ATCC 8043).从粪肠球菌（ATCC 8043）中分离叶酸还原酶。
J Bacteriol. 1969 Mar;97(3):1160-4. doi: 10.1128/jb.97.3.1160-1164.1969.
7
Dihydrofolate reductase of Streptococcus faecalis. I. Purification and some properties of reductase from the wild strain and from strain A.粪链球菌的二氢叶酸还原酶。I. 野生菌株和A菌株还原酶的纯化及某些性质
J Biol Chem. 1966 Jul 10;241(13):2995-3001.
8
Differentiating properties of the dihydrofolate reductases of amethopterin-resistant Streptococcus faecalis/Ak and the sensitive parent strain.抗氨甲蝶呤粪肠球菌/Ak及其敏感亲本菌株二氢叶酸还原酶的鉴别特性
J Biol Chem. 1966 Mar 10;241(5):1043-8.

氨甲蝶呤敏感的粪肠球菌变种耐久肠球菌的叶酸还原酶和特异性二氢叶酸还原酶活性。

Folate reductase and specific dihydrofolate reductase activities of the amethopterin-sensitive Streptococcus faecium var. durans.

作者信息

Albrecht A M, Hutchison D J

出版信息

J Bacteriol. 1969 Oct;100(1):533-4. doi: 10.1128/jb.100.1.533-534.1969.

DOI:10.1128/jb.100.1.533-534.1969
PMID:5344115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC315426/
Abstract

Preliminary evidence is presented that indicates that the dihydrofolate reductase activity of amethopterin-sensitive Streptococcus faecium var. durans ATCC 8043 is separable into two dihydrofolate reductases, one of which also reduces folate.

摘要

初步证据表明，对氨甲蝶呤敏感的粪肠球菌耐久亚种ATCC 8043的二氢叶酸还原酶活性可分为两种二氢叶酸还原酶，其中一种还能还原叶酸。