新生儿甲状腺功能减退对大鼠脑内酮体代谢酶发育的影响。
Influence of neonatal hypothyroidism on the development of ketone-body-metabolizing enzymes in rat brain.
作者信息
Patel M S
出版信息
Biochem J. 1979 Oct 15;184(1):169-72. doi: 10.1042/bj1840169.
Abstract
Neonatal hypothyroidism markedly retarded the postnatal development of three ketone-body-metabolizing enzymes in rat brain during the first 4 weeks after birth. In contrast with normal animals, the brains of hypothyroid rats did not show decreases in the activities of these enzymes during the immediate postweaning period. The activities of ketone-body-oxidizing enzymes were markedly diminished in both non-synaptic and synaptic mitochondria isolated from 4-week-old hypothyroid rats compared with age-matched normal animals.
摘要
新生儿甲状腺功能减退显著延缓了出生后最初4周大鼠脑中三种酮体代谢酶的产后发育。与正常动物相比，甲状腺功能减退大鼠的大脑在刚断奶期间这些酶的活性并未降低。与年龄匹配的正常动物相比，从4周龄甲状腺功能减退大鼠分离出的非突触线粒体和突触线粒体中，酮体氧化酶的活性均显著降低。
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