抗帕金森病药物：抑制纹状体中多巴胺摄取作为一种可能的作用机制。
Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action.
作者信息
Coyle J T, Snyder S H
出版信息
Science. 1969 Nov 14;166(3907):899-901. doi: 10.1126/science.166.3907.899.
PMID:5345207
Abstract
A variety of antiparkinsonian drugs are potent, noncompetitive inhibitors of dopamine uptake into synaptosomes in homogenates of rat corpus striatum. Inhibition of dopamine uptake may potentiate the synaptic actions of dopamine in the striatum and could explain the antiparkinsonian effects of these drugs. This hypothesis accounts for several clinical features of Parkinson's disease and predicts compounds which may be new therapeutic agents.
摘要
多种抗帕金森病药物是大鼠纹状体匀浆中突触体摄取多巴胺的强效非竞争性抑制剂。抑制多巴胺摄取可能会增强纹状体中多巴胺的突触作用，这可以解释这些药物的抗帕金森病作用。这一假说解释了帕金森病的几个临床特征，并预测了可能成为新治疗药物的化合物。
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