水溶液中[甲硫氨酸]脑啡肽和β-内啡肽的质子磁共振研究。

Proton magnetic resonance studies on [methionine]-enkephalin and beta-endorphin in aqueous solution.

作者信息

Levine B A, Rabenstein D L, Smyth D, Williams R J

出版信息

Biochim Biophys Acta. 1979 Aug 28;579(2):279-90. doi: 10.1016/0005-2795(79)90055-2.

Abstract

Proton magnetic resonance studies of [Met5]-enkephalin (lipotropin 61-65) in aqueous solution indicate a conformational preference for the pentapeptide backbone. The structural differences between [Met5]-enkephalin and other, more flexible peptides have been investigated using paramagnetic probe techniques. An outline structure for beta-endorphin (lipotropin 61-91) in aqueous solution is obtained from binding studies using Gd(III) as a relaxation probe.

摘要

对水溶液中[Met5]-脑啡肽（促脂素61 - 65）的质子磁共振研究表明，五肽主链存在构象偏好。已使用顺磁探针技术研究了[Met5]-脑啡肽与其他更具柔性的肽之间的结构差异。通过使用钆（III）作为弛豫探针的结合研究，获得了水溶液中β-内啡肽（促脂素61 - 91）的轮廓结构。