Jacques J
Br J Exp Pathol. 1969 Oct;50(5):486-9.
Lathyrism, which affects developing connective tissue, is produced by extracts of sweet-pea seeds (Lathyrus odoratus) and by various amino-nitriles. The basic lesion is a defect in the intra- and inter-molecular bonding of collagen, as a result of which wound tensile strength is diminished. Wounds involving skin loss in rats heal largely by a process known as contraction, in which the skin edges are brought together, leaving only a small defect to be closed by the migrating epithelium. Here, it has been found that a lathyrogenic agent (β-aminopropionitrile) has no effect on wound contraction and the implications of this are discussed. The result suggests that tensile strength and contraction reflect different aspects of healing.
山黧豆中毒会影响发育中的结缔组织，它由香豌豆种子（香豌豆）提取物和各种氨基腈产生。基本病变是胶原蛋白分子内和分子间结合存在缺陷，其结果是伤口抗张强度降低。大鼠皮肤缺损的伤口主要通过一种称为收缩的过程愈合，在此过程中皮肤边缘靠拢，仅留下一个小缺损由迁移的上皮细胞封闭。在此，已发现一种致山黧豆中毒因子（β-氨基丙腈）对伤口收缩没有影响，并对其影响进行了讨论。结果表明抗张强度和收缩反映了愈合的不同方面。
