Sgoutas D S, Sanders H, Yang E M
J Lipid Res. 1969 Nov;10(6):642-5.
Methyl esters of polyunsaturated fatty acids labeled with tritium were prepared by partial stereoselective reduction of the corresponding acetylenic esters with tritiated disiamylborane, followed by protonolysis with tritiated acetic acid. The labeling was strictly specific, and the tritium atoms were located only at the carbon atoms forming the unsaturated bond(s). Synthesis of some tritiated fatty acid methyl esters with methylene-interrupted trans-cis double bonds is also reported.
用氚化二异戊基硼对相应的炔酸酯进行部分立体选择性还原，然后用氚化乙酸进行质子解反应，制备了用氚标记的多不饱和脂肪酸甲酯。标记具有严格的特异性，氚原子仅位于形成不饱和键的碳原子上。还报道了一些具有亚甲基间断的反式-顺式双键的氚化脂肪酸甲酯的合成。
