头孢氨苄：一种新型头孢菌素抗生素吸收与排泄的人体研究
Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic.
作者信息
Gower P E, Dash C H
出版信息
Br J Pharmacol. 1969 Nov;37(3):738-47. doi: 10.1111/j.1476-5381.1969.tb08513.x.
Abstract
- Serum levels, half-lives and urine concentrations of cephalexin, an oral cephalosporin antibiotic which is unique in its absorption and excretion, are reported in human volunteers, fasting, non-fasting and non-fasting plus probenecid. Accumulation does not seem to occur.2. Cephalexin clearance was 376 ml./min and the ratio of cephalexin/creatinine clearances was 2.6 in one volunteer.3. Cephalexin had no effect on the urinary excretion of leucocytes, red cells or protein.4. The very high rate of absorption giving high serum levels and urine concentrations suggest cephalexin will be a useful antibiotic in susceptible bacterial infections in man.
摘要
已报告口服头孢菌素抗生素头孢氨苄在人体志愿者中，包括空腹、非空腹以及非空腹加丙磺舒状态下的血清水平、半衰期和尿液浓度。头孢氨苄在吸收和排泄方面独具特点，似乎不会发生蓄积。
在一名志愿者中，头孢氨苄清除率为376毫升/分钟，头孢氨苄与肌酐清除率之比为2.6。
头孢氨苄对白细胞、红细胞或蛋白质的尿排泄无影响。
极高的吸收率导致高血清水平和尿液浓度，这表明头孢氨苄将成为治疗人类易感细菌感染的一种有用抗生素。
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