Khan H, Bingham J R
Can Med Assoc J. 1969 Nov 1;101(9):74-7.
Four different groups of subjects were given Histalog, insulin or reserpine or acted as controls. Changes were noted in gastric emptying, acid, chloride, parietal and non-parietal secretions and neutral chloride. Gastric emptying and secretion were measured by the Hunt and Spurrell test meal as modified by us for drug testing.Histalog stimulated gastric secretion but not emptying. Insulin stimulated both secretion and emptying. Reserpine stimulated secretion but it stimulated emptying only in one-half of the subjects.After Histalog and reserpine the rise in hydrogen and chloride secretion was equal, so the neutral chloride did not increase. After insulin the rise of chloride was proportionately greater than the rise of hydrogen, so that neutral chloride was increased.
四组不同的受试者分别给予组织胺、胰岛素、利血平或作为对照。观察了胃排空、胃酸、氯离子、壁细胞和非壁细胞分泌以及中性氯的变化。胃排空和分泌通过我们为药物测试修改后的亨特和斯珀雷尔试餐法进行测量。组织胺刺激胃液分泌但不刺激胃排空。胰岛素刺激分泌和排空。利血平刺激分泌，但仅在一半受试者中刺激胃排空。给予组织胺和利血平后，氢离子和氯离子分泌的增加量相等，因此中性氯没有增加。给予胰岛素后，氯离子的增加量比氢离子的增加量成比例地更大，因此中性氯增加。
