Grzybowski S, Ashley M J, McKinnon N E, Pinkus G, Philipps R, Brown A
Can Med Assoc J. 1969 Nov 1;101(9):81-6.
One thousand five hundred and thirty-six patients with inactive tuberculosis were given a course of preventive treatment consisting of either INH alone or INH and PAS while 840 similar patients served as a control group. Discontinuation of the treatment was frequent and was usually caused by development of complaints which the patients ascribed to the drugs they were taking.The annual reactivation rate among controls was 4.9 per 1000. During the period of taking drugs the treated group suffered a reactivation rate of 0.7 per 1000 and those who had taken the medication for at least six months suffered a subsequent annual reactivation rate of 1.3 per 1000. The rate for those who discontinued treatment in the first six months was 5.1 per 1000. There were no reactivations in patients who took INH and PAS for over six months. Bacilli from two of the patients with reactivations who were treated for a prolonged period with INH alone showed resistance to this drug.Chemoprophylaxis of inactive cases is a potent weapon in tuberculosis control; however, it requires thorough motivation and supervision.
1536例非活动性结核病患者接受了一个疗程的预防性治疗，治疗方案为单独使用异烟肼（INH）或异烟肼与对氨基水杨酸（PAS）联合使用，同时840例类似患者作为对照组。治疗中断情况频繁，通常是由患者归因于所服用药物的不适症状引发的。对照组的年复发率为每1000人中有4.9例。在服药期间，治疗组的复发率为每1000人中有0.7例，而那些服药至少6个月的患者随后的年复发率为每1000人中有1.3例。在头6个月内停药的患者的复发率为每1000人中有5.1例。服用异烟肼和对氨基水杨酸超过6个月的患者没有复发情况。在接受长时间单独异烟肼治疗后复发的2例患者中，其杆菌对该药物表现出耐药性。对非活动性病例进行化学预防是结核病控制中的一项有力武器；然而，这需要患者有充分的积极性和监督。
