Fisher M, Akhtar A J, Calder M A, Moffat M A, Stewart S M, Zealley H, Crofton J W
Br Med J. 1969 Oct 25;4(5677):187-92. doi: 10.1136/bmj.4.5677.187.
The factors associated with exacerbations of chronic bronchitis were investigated in a pilot study of 23 male patients over a period of 29 months. There were 63 exacerbations-56 were fully investigated and in seven only serological studies were possible. Evidence of the presence of an infective agent was sought in the early stages of the exacerbations and during relative quiescence. Significantly more potential pathogens, both bacterial (pneumococci and Haemophilus influenzae) and viral and mycoplasmal, were found during exacerbations than in quiescent periods. It was not possible to demonstrate that atmospheric pollution or low temperature influenced exacerbations, but the data are insufficient to exclude a small effect.It is emphasized that the value of future work on these lines would be increased if agreement could be reached on the definition of an exacerbation.
在一项针对23名男性患者、为期29个月的初步研究中，对与慢性支气管炎加重相关的因素进行了调查。共有63次加重发作，其中56次进行了全面调查，7次仅进行了血清学研究。在加重发作的早期阶段以及病情相对缓解期间，探寻了感染因子存在的证据。与病情缓解期相比，在加重发作期间发现的潜在病原体明显更多，包括细菌（肺炎球菌和流感嗜血杆菌）、病毒和支原体。无法证明大气污染或低温会影响病情加重，但现有数据不足以排除轻微影响。需要强调的是，如果能就病情加重的定义达成一致，那么未来在这些方面的研究价值将会提高。
