Yasake W J, Eichbaum F W, Oga S
Cardiovasc Res. 1979 Dec;13(12):711-6. doi: 10.1093/cvr/13.12.711.
The effect of propylene glycol, benzyl alcohol, quinidine, and procainamide on the effective refractory period of isolated rabbit atria were compared. The lengthening of effective refractory period reached its maximum at approximately 10 min for solvents and 40 to 50 min for quinidine and procainamide. The slopes of the effective refractory period curves were similar for propylene glycol and benzyl alcohol. The slopes of the effective refractory period curves for quinidine and procainamide were similar, but they differed from those obtained with propylene glycol and benzyl alcohol. These differences suggest that propylene glycol and benzyl alcohol lengthen the effective refractory period by different mechanism than that of quinidine and procainamide. The effective dose 50% required for lengthening the effective refractory period is 20-fold greater for quinidine than for procainamide with similar relative responsiveness. On the other hand, the solvents showed low affinity and low relative responsiveness, although the combination of propylene glycol and benzyl alcohol showed similar relative responsiveness to procainamide. Despite the fact that these solvents have a lower antiarrhythmic potency, their therapeutic index is 5- to 50-fold greater than quinidine and/or procainamide.
比较了丙二醇、苯甲醇、奎尼丁和普鲁卡因胺对离体兔心房有效不应期的影响。溶剂使有效不应期延长在约10分钟时达到最大值，奎尼丁和普鲁卡因胺则在40至50分钟时达到最大值。丙二醇和苯甲醇的有效不应期曲线斜率相似。奎尼丁和普鲁卡因胺的有效不应期曲线斜率相似，但与丙二醇和苯甲醇的不同。这些差异表明，丙二醇和苯甲醇延长有效不应期的机制与奎尼丁和普鲁卡因胺不同。在相对反应性相似的情况下，奎尼丁延长有效不应期所需的半数有效剂量比普鲁卡因胺大20倍。另一方面，尽管丙二醇和苯甲醇的组合显示出与普鲁卡因胺相似的相对反应性，但溶剂显示出低亲和力和低相对反应性。尽管这些溶剂的抗心律失常效力较低，但其治疗指数比奎尼丁和/或普鲁卡因胺高5至50倍。
