正常血压和高血压大鼠的血管平滑肌反应性
Vascular smooth muscle reactivity in normotensive and hypertensive rats.
作者信息
Spector S, Fleisch J H, Maling H M, Brodie B B
出版信息
Science. 1969 Dec 5;166(3910):1300-1. doi: 10.1126/science.166.3910.1300.
PMID:5350331
Abstract
Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Thus, hypertension is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle.
摘要
自发性高血压大鼠的主动脉条对去甲肾上腺素、5-羟色胺和氯化钾的收缩作用反应比正常动物弱，但对β受体激动剂异丙肾上腺素的舒张作用反应更强。因此，高血压并非是由于β受体缺乏或血管平滑肌超敏所致。
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