胎儿类固醇代谢的研究。人胎儿肝脏中6-α-羟基睾酮的生物合成。
Studies on the metabolism of steroids in the foetus. Biosynthesis of 6-alpha-hydroxytestosterone in the human foetal liver.
作者信息
Lisboa B P, Gustafsson J A
出版信息
Biochem J. 1969 Nov;115(3):583-6. doi: 10.1042/bj1150583.
Abstract
After incubation of testosterone with 105000g microsomes of human foetal liver, 6alpha-hydroxytestosterone was isolated and identified by t.l.c. and g.l.c.-mass spectrometry. This is the first example of 6alpha-hydroxylation of C(19) steroids in the human liver, and the finding is discussed in relation to earlier reports of 6-oxygenated C(19) and C(18) steroids in pregnant women.
摘要
将睾酮与人胎儿肝脏的105000g微粒体一起温育后，通过薄层层析和气相色谱 - 质谱法分离并鉴定出6α - 羟基睾酮。这是人类肝脏中C(19)类固醇6α - 羟基化的首个实例，并且结合孕妇中C(19)和C(18)类固醇6 - 氧化的早期报告对该发现进行了讨论。
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