麻醉犬血细胞比容急性变化对尿量及尿液性质的影响。
The effect of acute changes in haematocrit in the anaesthetized dog on the volume and character of the urine.
作者信息
Nashat F S, Scholefield F R, Tappin J W, Wilcox C S
出版信息
J Physiol. 1969 Nov;205(2):305-16. doi: 10.1113/jphysiol.1969.sp008966.
Abstract
- Acute changes in haematocrit were produced by exchange transfusion of dextran-in-saline or packed red cells.2. There were no significant changes in glomerular filtration rate, blood pressure, central venous pressure, heart rate, respiratory rate, blood volume or extracellular fluid volume following the exchange transfusions.3. Urine volume increased after haemodilution but decreased after haemoconcentration.4. The diuresis after haemodilution occurred despite an infusion of ADH or alcohol. Thus it could not be attributed to a change in circulating ADH level.5. There were two types of diuresis. The ;water diuretic' response was characterized by an increase in free water clearance with a reduction in urinary sodium concentration; the ;sodium diuretic' response by an increase in urinary sodium concentration but no change, or a fall, in free water clearance.6. The results were related to changes in medullary osmotic gradient found by other workers to occur when medullary blood flow rate is altered.
摘要
通过输注葡聚糖生理盐水或浓缩红细胞进行换血，可引起血细胞比容的急性变化。
换血后，肾小球滤过率、血压、中心静脉压、心率、呼吸频率、血容量或细胞外液量均无显著变化。
血液稀释后尿量增加，血液浓缩后尿量减少。
尽管输注了抗利尿激素或酒精，血液稀释后仍会出现利尿现象。因此，这不能归因于循环中抗利尿激素水平的变化。
存在两种类型的利尿。“水利尿”反应的特征是自由水清除率增加，尿钠浓度降低；“钠利尿”反应的特征是尿钠浓度增加，但自由水清除率无变化或降低。
这些结果与其他研究人员发现的当髓质血流速度改变时髓质渗透梯度的变化有关。
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