Akiba K, Miyamoto A, Suzuki T, Anezaki K, Tadano T, Sakurada S, Kisara K
Nihon Yakurigaku Zasshi. 1979 May;75(4):383-90. doi: 10.1254/fpj.75.383.
The action of d-psuedoephedrine on bronchial smooth muscle, respiratory resistance and blood pressure was compared with that of 1-ephedrine. The following results were obtained. 1) Administration of dl-isoproterenol on isolated guinea pig tracheal muscle previously constricted with acetylcholine (ACh) or histamine (his) was the most effective and d-pseudoephedrine had the same effect as 1-ephedrine. The relaxing effect of dl-isoproterenol, 1-ephedrine or d-pseudoephedrine on ACh or His induced tracheal constriction was competitively antagonized by the pretreatment of propranolol. 2) The intravenous or sublingual administration of d-pseudoephedrine on the increased respiratory resistance induced by His produced the same effect as 1-ephedrine. 3) The increase in blood pressure with d-pseudoephedrine was weaker than that of 1-ephedrine. 4) When 1-ephedrine of d-pseudoephedrine was repeatedly injected into the same animal, signs of tachyphylaxis were observed. It was found that d-pseudoephedrine, the main alkaloid of Ephedrine Helba, exhibited the relaxing effect on bronchial smooth muscles as did 1-ephedrine. The respiratory resistance increased by His was inhibited by the sublingual administration of d-pseudoephedrine and 1-ephedrine.
将d-伪麻黄碱对支气管平滑肌、呼吸阻力和血压的作用与l-麻黄碱进行了比较。得到以下结果。1）对预先用乙酰胆碱（ACh）或组胺（his）收缩的豚鼠离体气管肌给予dl-异丙肾上腺素最为有效，d-伪麻黄碱与l-麻黄碱具有相同的作用。普萘洛尔预处理可竞争性拮抗dl-异丙肾上腺素、l-麻黄碱或d-伪麻黄碱对ACh或His诱导的气管收缩的舒张作用。2）对His诱导的呼吸阻力增加静脉注射或舌下给予d-伪麻黄碱，其作用与l-麻黄碱相同。3）d-伪麻黄碱引起的血压升高比l-麻黄碱弱。4）当对同一动物反复注射l-麻黄碱或d-伪麻黄碱时，观察到快速耐受性的迹象。发现d-伪麻黄碱（麻黄的主要生物碱）对支气管平滑肌具有与l-麻黄碱相同的舒张作用。舌下给予d-伪麻黄碱和l-麻黄碱可抑制His引起的呼吸阻力增加。
