Anezaki K, Ando R, Sakurada T, Tadano T, Kisara K
Nihon Yakurigaku Zasshi. 1979 May;75(4):391-7. doi: 10.1254/fpj.75.391.
Effects of diazepam were examined on the whine reaction elicited by LH stimulation and on unit activities in the LH and Abm in cats. The spontaneous firing frequency of Abm neurons was 5 to 30 spikes/sec and in all 6 neurons isolated the firing frequency increased by non-nociceptive and/or clap-stimulation. Diazepam decreased the spontaneous firing frequency of all Abm neurons isolated and the increased firing frequency elicited by non-nociceptive and/or clap-stimulation was also depressed by diazepam. The spontaneous firing frequency of neurons in the LH was 4 to 5 spikes/sec and all 6 neurons isolated firing frequency increased by non-nociceptive stimulation. Only one of 6 neurons, however, was activated by clap-stimulation. Diazepam decreased the spontaneous firing frequency of all LH neurons. Out of 6 neurons responsive to non-nociceptive stimulation, 3 were also depressed by diazepam. The other neurons were not affected by diazepam. These results suggest that depressed action of diazepam on the whine reaction elicited by the LH stimulation may be related to the decrease of firing in the Abm and/or the LH by diazepam.
研究了地西泮对猫下丘脑外侧区（LH）刺激诱发的哀鸣反应以及对LH和杏仁核基底内侧核（Abm）单位活动的影响。Abm神经元的自发放电频率为5至30次/秒，在分离出的所有6个神经元中，非伤害性刺激和/或拍手刺激会使放电频率增加。地西泮降低了所有分离出的Abm神经元的自发放电频率，并且地西泮也抑制了由非伤害性刺激和/或拍手刺激引起的放电频率增加。LH中神经元的自发放电频率为4至5次/秒，分离出的所有6个神经元的放电频率因非伤害性刺激而增加。然而，在6个神经元中只有1个被拍手刺激激活。地西泮降低了所有LH神经元的自发放电频率。在对非伤害性刺激有反应的6个神经元中，有3个也被地西泮抑制。其他神经元不受地西泮影响。这些结果表明，地西泮对LH刺激诱发的哀鸣反应的抑制作用可能与地西泮使Abm和/或LH放电减少有关。
