Takahashi R, Nakane Y, Akiyama A
Folia Psychiatr Neurol Jpn. 1979;33(4):501-9. doi: 10.1111/j.1440-1819.1979.tb03188.x.
The double-blind controlled studies on lithium carbonate therapy conducted in Japan have demonstrated that there are no significant correlations between clinical effectiveness and serum lithium level in manic patients as well as depressed patients and also that Japanese patients seem to require less lithium carbonate than their U.S. counterparts as an effective therapeutic dose, both in terms of mean maximum dose and serum level. Although any international comparison cannot be fully valid without using transculturally standardized assessment, the data of these studies were examined from the viewpoint of transcultural psychopharmacology and compared to the data from studies in U.S.A.
在日本进行的关于碳酸锂治疗的双盲对照研究表明，无论是躁狂患者还是抑郁患者，临床疗效与血清锂水平之间均无显著相关性，而且日本患者作为有效治疗剂量所需的碳酸锂似乎比美国患者少，无论是平均最大剂量还是血清水平方面。尽管在没有使用跨文化标准化评估的情况下，任何国际比较都不可能完全有效，但这些研究的数据从跨文化精神药理学的角度进行了审视，并与美国研究的数据进行了比较。
