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作为胰腺功能测试,比较十二指肠胰蛋白酶活性测定和75硒-硒蛋氨酸胰腺扫描。

Measurement of duodenal tryptic activity and 75Se-selenomethionine pancreatic scanning compared as tests of pancreatic function.

作者信息

McCarthy D M, Brown P

出版信息

Gut. 1969 Nov;10(11):913-20. doi: 10.1136/gut.10.11.913.

DOI:10.1136/gut.10.11.913
PMID:5358582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553064/
Abstract

The results of a subjective assessment of pancreatic function, based on the appearance of a (75)Se-pancreatic scan, were compared with measurements of the tryptic activity of duodenal aspirates in 16 normal and 38 abnormal subjects. In normals and in abnormals whose scans showed a generalized rather than a localized abnormality there was close agreement between the results of the two sets. In patients with a localized abnormality of the pancreatic head on scanning the tryptic activity of the aspirate was useful in differentiating carcinoma of the pancreas from that of the common bile duct. In general the scan was the more discriminative test though otherwise the places of the two tests in diagnosis are rather similar. The particular situations in which each test is valuable, or in which one or other test can be omitted, are discussed.

摘要

基于(75)硒胰腺扫描的表现,对16名正常人和38名异常受试者的胰腺功能进行主观评估,其结果与十二指肠抽吸物胰蛋白酶活性的测量结果进行了比较。在扫描显示为全身性而非局限性异常的正常人和异常受试者中,两组结果之间密切一致。在扫描显示胰头部有局限性异常的患者中,抽吸物的胰蛋白酶活性有助于鉴别胰腺癌和胆总管癌。一般来说,扫描是更具鉴别力的检查,不过在其他方面,这两项检查在诊断中的作用相当相似。文中讨论了每项检查有价值的具体情况,或可以省略其中一项或另一项检查的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/978b/1553064/0a7dd42e04c6/gut00701-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/978b/1553064/0a7dd42e04c6/gut00701-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/978b/1553064/0a7dd42e04c6/gut00701-0055-a.jpg

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引用本文的文献

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Radiologic and isotopic investigation of the pancreas.胰腺的放射学和同位素检查
Proc R Soc Med. 1970 May;63(5):434-6. doi: 10.1177/003591577006300503.
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Trypsin and chymotrypsin as aids in the diagnosis of pancreatic disease.胰蛋白酶和胰凝乳蛋白酶辅助诊断胰腺疾病。
Am J Dig Dis. 1972 Sep;17(9):780-92. doi: 10.1007/BF02231147.
3
75 Se-selenomethionine scanning in the diagnosis of tumours of the pancreas and adjacent viscera: the use of the test and its impact on survival.75硒-硒代蛋氨酸扫描在胰腺及相邻脏器肿瘤诊断中的应用:检查方法及其对生存的影响

本文引用的文献

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Studies in pancreatic function. IV. The use of the secretin test in the diagnosis of tumors in and about the pancreas.
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Factors influencing duodenal trypsin levels following a standard test meal as a test of pancreatic function.作为胰腺功能测试的标准试餐后影响十二指肠胰蛋白酶水平的因素。
Gut. 1974 Mar;15(3):173-9. doi: 10.1136/gut.15.3.173.
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Simultaneous combined pancreatic test.同步联合胰腺试验
Br Med J. 1974 Jan 19;1(5898):87-90. doi: 10.1136/bmj.1.5898.87.
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An evaluation of 75 Se selenomethionine scanning as a test of pancreatic function compared with the secretin-pancreozymin test.将75硒蛋氨酸扫描作为胰腺功能检测方法与促胰液素-胰酶泌素试验的比较评估。
Gut. 1973 May;14(5):383-9. doi: 10.1136/gut.14.5.383.
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The Lundh test.伦德试验。
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Pancreatic scanning as a diagnostic tool in the district general hospital.胰腺扫描作为地区综合医院的一种诊断工具。
Br Med J. 1974 Oct 19;4(5937):153-6. doi: 10.1136/bmj.4.5937.153.
4
EXTERNAL PANCREATIC SECRETION IN DIABETES MELLITUS.糖尿病患者的胰腺外分泌功能
Ann Intern Med. 1963 Dec;59:812-21. doi: 10.7326/0003-4819-59-6-812.
5
INCORPORATION OF SE75-SELENOMETHIONINE INTO PANCREATIC JUICE PROTEINS IN VIVO.体内将硒代蛋氨酸(Se75)掺入胰液蛋白质中。
Biochem Biophys Res Commun. 1963 Sep 10;13:71-4. doi: 10.1016/0006-291x(63)90165-7.
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Roentgenologic diagnosis of pancreatic disease.
Am J Roentgenol Radium Ther Nucl Med. 1967 Jul;100(3):664-72. doi: 10.2214/ajr.100.3.664.
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Measurement of tryptic activity in intestinal juice as a diagnostic test of pancreatic disease.测定肠液中的胰蛋白酶活性作为胰腺疾病的诊断试验。
Gut. 1967 Aug;8(4):408-14. doi: 10.1136/gut.8.4.408.
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Exocrine pancreatic function in diabetes mellitus.糖尿病中的胰腺外分泌功能。
S Afr Med J. 1967 Aug 12;41(30):756-8.
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Pancreatic scanning.
Radiology. 1966 Oct;87(4):641-5. doi: 10.1148/87.4.641.
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Gas-distension, double-contrast duodenography using the Scott-Harden gastroduodenal tube.使用斯科特-哈登胃十二指肠管进行气胀性双对比十二指肠造影。
Gut. 1966 Aug;7(4):420-4. doi: 10.1136/gut.7.4.420.