巴巴多斯的脊髓灰质炎、风疹和登革热抗体调查。一项随访研究。

Poliomyelitis, rubella, and dengue antibody survey in Barbados. A follow-up study.

作者信息

Evans A S, Wells A V, Ramsay F, Drabkin P, Palmer K

出版信息

Int J Epidemiol. 1979 Sep;8(3):235-41. doi: 10.1093/ije/8.3.235.

DOI:10.1093/ije/8.3.235

Abstract

A follow-up study of poliomyelitis, rubella, and dengue antibodies has been made in light of results obtained in a 1972 health and serological survey in Barbados, W.I. Poliomyelitis antibody neutralization tests performed on sera from 307 children under age 15 using overnight serum/virus mixtures on microtiter plates at low serum dilutions revealed the absence of polio antibody at 1:2 dilution in 13.7% for type 1, 6.5% for type 2, and 14.3% for type 3 virus. A significant correlation of the presence or absence of poliomyelitis antibody to types 2 and 3 was seen with the response to immunization histories. Forty-three of 49 girls (88%) given rubella vaccine (RA 27/3) in 1972 had demonstrable haemagglutination-inhibition antibody 4 years later. Neutralization tests for dengue antibody confirmed the results of the complement-fixation tests and indicated that type 2 was probably the sole infecting strain.

摘要

根据1972年在西印度群岛巴巴多斯进行的健康和血清学调查结果，对小儿麻痹症、风疹和登革热抗体进行了一项随访研究。使用微量滴定板在低血清稀释度下将过夜血清/病毒混合物用于对15岁以下307名儿童的血清进行小儿麻痹症抗体中和试验，结果显示，1型病毒在1:2稀释度时13.7%的血清中未检出脊髓灰质炎抗体，2型为6.5%，3型为14.3%。2型和3型脊髓灰质炎抗体的有无与免疫接种史的反应存在显著相关性。1972年接种风疹疫苗（RA 27/3）的49名女孩中有43名（88%）在4年后检测到血凝抑制抗体。登革热抗体中和试验证实了补体结合试验的结果，并表明2型可能是唯一的感染毒株。