Joó I, Zsidai J
J Biol Stand. 1979;7(4):341-8. doi: 10.1016/s0092-1157(79)80008-6.
Fluid plain and adsorbed and freeze-dried cholera and tyhpoid vaccines of different composition were examined for thermostability by potency testing (by active mouse protection tests) after exposure to 37 degrees C for 1, 2, 3, 4, 8 and 12 weeks. Loss of potency was evaluated by comparison with samples stored at 4 degrees C. The fluid plain cholera vaccine remained fully potent for 1--3 weeks, the adsorbed vaccine for at least 4 weeks. The fluid typhoid vaccines showed greater thermosensitivity than the fluid plain cholera vaccine. The freeze-dried cholera and typhoid vaccines were both very stable, retaining fully potency after at least 12 weeks' exposure to 37 degrees C. It should be emphasized that the above results apply exclusively to vaccines prepared by the methods used by the authors and formulated to identical compositions.
对不同成分的液体普通型、吸附型以及冻干型霍乱和伤寒疫苗，在37℃分别暴露1、2、3、4、8和12周后，通过效价检测（活性小鼠保护试验）来检查其热稳定性。通过与保存在4℃的样品比较来评估效力损失。液体普通型霍乱疫苗在1至3周内保持完全效力，吸附型疫苗至少4周保持完全效力。液体伤寒疫苗比液体普通型霍乱疫苗表现出更高的热敏感性。冻干型霍乱和伤寒疫苗都非常稳定，在37℃暴露至少12周后仍保持完全效力。应当强调，上述结果仅适用于采用作者所使用方法制备且配方相同的疫苗。
