• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

患有黏液黏稠症的男婴的先天性中肾缺陷。

Congenital mesonephric defects in male infants with mucoviscidosis.

作者信息

Olson J R, Weaver D K

出版信息

J Clin Pathol. 1969 Nov;22(6):725-30. doi: 10.1136/jcp.22.6.725.

DOI:10.1136/jcp.22.6.725
PMID:5365348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC474368/
Abstract

Reports that men with mucoviscidosis were sterile and that portions of their genital tracts were atretic prompted us to investigate the genital tracts of 15 male infants with mucoviscidosis who died within the first year of life and came to necropsy. The genital tracts of all of these infants were abnormal, the abnormalities being confined to mesonephric derivatives. Hypoplastic or absent ducti efferentia, ducti epididymides, or ducti deferentia were found in all 28 specimens of epididymides, and the ducti deferentia were missing from 25 of 27 examples of spermatic cord. The seminal vesicles and the ejaculatory ducts were less frequently hypoplastic or absent. Because these abnormalities of mesonephric derivatives were present so early in life and inflammatory and obstructive changes were absent we believe that they resulted from a failure of development.

摘要

有报告称，患有黏液黏稠病的男性不育，其生殖道部分闭锁，这促使我们对15名在出生后第一年内死亡并进行尸检的患有黏液黏稠病的男婴的生殖道进行研究。所有这些婴儿的生殖道均异常，异常仅限于中肾衍生物。在所有28个附睾标本中均发现输出小管、附睾管或输精管发育不全或缺失，在27个精索标本中有25个缺失输精管。精囊和射精管发育不全或缺失的情况较少见。由于这些中肾衍生物的异常在生命早期就已出现，且不存在炎症和阻塞性改变，我们认为它们是发育失败所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/13340dff8820/jclinpath00383-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/5d38b44ea3fa/jclinpath00383-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/4203d2a86856/jclinpath00383-0101-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/cfe1b90887ed/jclinpath00383-0101-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/524515c2b689/jclinpath00383-0101-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/d36bd57a2eb3/jclinpath00383-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/1704d14f870a/jclinpath00383-0102-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/5a1b70b659de/jclinpath00383-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/13340dff8820/jclinpath00383-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/5d38b44ea3fa/jclinpath00383-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/4203d2a86856/jclinpath00383-0101-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/cfe1b90887ed/jclinpath00383-0101-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/524515c2b689/jclinpath00383-0101-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/d36bd57a2eb3/jclinpath00383-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/1704d14f870a/jclinpath00383-0102-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/5a1b70b659de/jclinpath00383-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8911/474368/13340dff8820/jclinpath00383-0103-b.jpg

相似文献

1
Congenital mesonephric defects in male infants with mucoviscidosis.患有黏液黏稠症的男婴的先天性中肾缺陷。
J Clin Pathol. 1969 Nov;22(6):725-30. doi: 10.1136/jcp.22.6.725.
2
Genital abnormalities in male patients with cystic fibrosis.
J Urol. 1971 Oct;106(4):568-74. doi: 10.1016/s0022-5347(17)61343-0.
3
[Malformations of Wolffian duct derived male genital organs (epididymis, vas deferens, seminal vesicules, ejaculatory ducts)].中肾管衍生男性生殖器官（附睾、输精管、精囊、射精管）的畸形
Prog Urol. 1997 Apr;7(2):262-9.
4
Amyloidosis of seminal vesicles and ejaculatory ducts: a histologic analysis of 21 cases among 447 prostatectomy specimens.精囊和射精管淀粉样变性：447例前列腺切除标本中21例的组织学分析
Ann Diagn Pathol. 2008 Aug;12(4):235-238. doi: 10.1016/j.anndiagpath.2007.12.004. Epub 2008 Apr 18.
5
Transrectal US of the seminal vesicles and ejaculatory ducts: clinical correlation.精囊和射精管的经直肠超声检查：临床相关性
Radiology. 1988 Sep;168(3):625-8. doi: 10.1148/radiology.168.3.3043543.
6
[Current problems of mucoviscidosis. Report of the 5th international conferfence on cystic fibrosis (mucoviscidosis) from 22nd-26th September 1969 in Cambridge England].[黏液黏稠症的当前问题。1969年9月22日至26日在英国剑桥举行的第5届国际囊性纤维化（黏液黏稠症）会议报告]
Dtsch Med Wochenschr. 1970 Jan 2;95(1):42-4.
7
CFTR gene mutations in men with bilateral ejaculatory-duct obstruction and anomalies of the seminal vesicles.双侧射精管梗阻及精囊异常男性的CFTR基因突变
Am J Hum Genet. 1997 Nov;61(5):1200-2. doi: 10.1086/301606.
8
[Congenital bilateral absence of ejaculatory duct with ectopic seminal vesicles].[先天性双侧射精管缺如伴异位精囊]
Hinyokika Kiyo. 1968 Mar;14(3):210-4.
9
Observations on cystic fibrosis of the pancreas. V. Developmental changes in the male genital system.胰腺囊性纤维化的观察。五、男性生殖系统的发育变化。
J Pediatr. 1969 Nov;75(5):806-11. doi: 10.1016/s0022-3476(69)80303-3.
10
Multicystic seminal vesicle with ipsilateral renal agenesis: two cases of Zinner syndrome.多囊性精囊伴同侧肾缺如：两例津纳综合征
Scand J Urol. 2017 Feb;51(1):81-84. doi: 10.1080/21681805.2016.1257650. Epub 2016 Dec 1.

引用本文的文献

1
Sonographic findings of the genital tract in boys with cystic fibrosis.患有囊性纤维化男孩生殖道的超声检查结果
Pediatr Radiol. 2006 Feb;36(2):162-6. doi: 10.1007/s00247-005-0055-4. Epub 2005 Dec 2.
2
CFTR gene mutations in men with bilateral ejaculatory-duct obstruction and anomalies of the seminal vesicles.双侧射精管梗阻及精囊异常男性的CFTR基因突变
Am J Hum Genet. 1997 Nov;61(5):1200-2. doi: 10.1086/301606.
3
Identification of a novel mutation in CFTR gene exon 8 (L375F) in a CUAVD phenotype.在先天性双侧输精管缺如（CUAVD）表型中鉴定出CFTR基因第8外显子的一种新突变（L375F）。

本文引用的文献

1
THE SECRETORY ACTIVITY OF THE MATURING EPIDIDYMIS COMPARED WITH MATURATIONAL CHANGES IN OTHER REPRODUCTIVE ORGANS OF THE FOETUS, INFANT AND CHILD.成熟附睾的分泌活动与胎儿、婴儿及儿童其他生殖器官成熟变化的比较
Acta Paediatr Scand. 1965 May;54:295-304. doi: 10.1111/j.1651-2227.1965.tb06372.x.
2
Congenital aplasia of the epididymides and vasa deferentia: effects on semen.先天性附睾和输精管发育不全：对精液的影响
Fertil Steril. 1963 Jan-Feb;14:44-8. doi: 10.1016/s0015-0282(16)34745-8.
3
Reproductive failure in males with cystic fibrosis.
Hum Genet. 1996 Apr;97(4):548-9. doi: 10.1007/BF02267085.
4
Congenital bilateral absence of the vas deferens and cystic fibrosis. A genetic commonality.先天性双侧输精管缺如与囊性纤维化。一种遗传共性。
World J Urol. 1993;11(2):82-8. doi: 10.1007/BF00182034.
5
Normal and abnormal development of the epididymis of the fetus and infant.
Eur J Pediatr. 1980 Jun;134(1):39-44. doi: 10.1007/BF00442401.
患有囊性纤维化的男性的生殖功能衰竭。
N Engl J Med. 1968 Jul 11;279(2):65-9. doi: 10.1056/NEJM196807112790203.
4
Guest editorial--fertility and the young adult with cystic fibrosis.特邀社论——生育与患有囊性纤维化的青年
N Engl J Med. 1968 Jul 11;279(2):103-5. doi: 10.1056/NEJM196807112790213.
5
Infertility in male patients with cystic fibrosis.
Pediatrics. 1968 Jan;41(1):7-17.
6
Cystic fibrosis of the pancreas. A generalised disturbance of water and electrolyte movement in exocrine tissues.
Lancet. 1968 Mar 2;1(7540):455-60.