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卷尾,一种小鼠中的轻度骨骼突变体。

Crinkly-tail, a mild skeletal mutant in the mouse.

作者信息

Johnson D R, Wallace M E

出版信息

J Embryol Exp Morphol. 1979 Oct;53:327-33.

PMID:536693
Abstract

Crinkly-tail, cy, is a new recessive mutant with imperfect penetrance, in chromosome 4 of the mouse. The only abnormality is in the shape of the vertebrae for one, more rarely two, lengths of the region C9 to C14. This is expressed briefly in the 11-day-old embryo as a duplicated tail gut. None of the mechanisms operating in most of the 20 known tail mutants in the mouse operates in crinkly-tail. The defect is probably due to misallocation of the tissue derived from the primitive streak.

摘要

卷尾(cy)是小鼠4号染色体上一种新的隐性突变体,具有不完全外显率。唯一的异常在于C9至C14区域一个(更罕见的是两个)椎体长度的椎骨形状。这在11日龄胚胎中短暂表现为尾肠重复。在小鼠已知的20种尾突变体中,大多数所涉及的机制在卷尾突变体中均不适用。该缺陷可能是由于原始条带衍生组织的错误分配所致。

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