Neirinckx R D, Holman B L, Davis M A, Zimmerman R E
J Nucl Med. 1979 Nov;20(11):1176-80.
Despite its 9.3-min half-life, Ta-178 can be used to produce radiopharmaceuticals for lung and liver imaging. A variety of human serum albumin microspheres and other particulate radiopharmaceuticals were labeled with Ta-178. A period of approximately 10 min was required for their preparation and administration to rats. Extrapolation to the clinical situation suggests that imaging could take place after one half-life of the nuclide has elapsed. We found that satisfactory imaging is possible using Ta-178 radiopharmaceuticals with the Anger camera and a pinhole collimator. Since short imaging times, high spatial resolution, and low patient doses are reasonable objectives in pediatric scintigraphy, these new radiotracers may prove useful for lung and liver imaging in children.
尽管Ta - 178的半衰期为9.3分钟，但它可用于制备用于肺部和肝脏成像的放射性药物。多种人血清白蛋白微球和其他颗粒状放射性药物都用Ta - 178进行了标记。制备并将其给予大鼠大约需要10分钟。外推至临床情况表明，在该核素的一个半衰期过去后即可进行成像。我们发现，使用配备针孔准直器的安格相机，用Ta - 178放射性药物能够获得令人满意的成像效果。由于短成像时间、高空间分辨率和低患者剂量是儿科闪烁扫描的合理目标，这些新型放射性示踪剂可能被证明对儿童肺部和肝脏成像有用。
