Kmet J P, Gerber F H, Raflo C P
J Nucl Med. 1979 Apr;20(4):294-6.
We investigated the possibility that acute administration of unlabeled stannous pyrophosphate may adversely affect red blood cells in the rabbit. Our method was similar to the in vivo labeling of RBCs with technetium-99m for blood-pool scanning. The investigation showed that dosages recommended in the literature produce no demonstrable difference between pre- and postdose RBC survival, which strongly suggests that the stannous content of the pharmaceutical is not harmful to red blood cells.
我们研究了急性给予未标记的焦磷酸亚锡可能对兔红细胞产生不利影响的可能性。我们的方法类似于用锝-99m对红细胞进行体内标记以进行血池扫描。研究表明，文献中推荐的剂量在给药前和给药后红细胞存活率之间没有可证明的差异，这有力地表明该药物中的亚锡含量对红细胞无害。
