潜在的抗炎化合物。3. 苊和茚衍生的化合物。

Potential antiinflammatory compounds. 3. Compounds derived from acenaphthene and indan.

作者信息

Smith C E, Williamson W R, Cashin C H, Kitchen E A

出版信息

J Med Chem. 1979 Dec;22(12):1464-9. doi: 10.1021/jm00198a007.

DOI:10.1021/jm00198a007

Abstract

Compounds having acenaphthene and indan as their parent nuclei were synthesized for antiinflammatory testing. Compounds which showed activity were 1-phenyl-5-acenaphthenylacetic acid and its alpha-methyl derivative (carrageenan rat paw edema) and the same alpha-methylacenaphthenylacetic acid and 2-(4-chlorobenzylidene)-3-oxo-5-indanacetic acid and its alpha-methyl derivative (rat adjuvant arthritis). None of the compounds was more active than the control compounds phenylbutazone and indomethacin.

摘要

合成了以苊和茚为母核的化合物用于抗炎测试。显示有活性的化合物有1-苯基-5-苊基乙酸及其α-甲基衍生物（角叉菜胶致大鼠足爪水肿模型），以及相同的α-甲基苊基乙酸和2-(4-氯亚苄基)-3-氧代-5-茚乙酸及其α-甲基衍生物（大鼠佐剂性关节炎模型）。没有一种化合物比对照化合物保泰松和吲哚美辛更具活性。

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