Anderson J A, Sweet P, Armentrout S A
J Clin Lab Immunol. 1979 Nov;2(4):285-91.
A factor in the sera of multiple sclerosis patients inhibits RNA, protein and DNA synthesis in actively metabolizing mitogen stimulated lymphocytes. Inhibition of macromolecular synthesis precedes cell death by 24 to 36 hours. The factor is effective on cells which are already committed to transformation by previous exposure to mitogen and cells which are simultaneously exposed to the factor and mitogen. Previous exposure of unstimulated cells to the factor does not alter their subsequent response to mitogen. The factor does not inhibit RNA synthesis of unstimulated lymphocytes isolated on a Ficoll-Hypaque gradient, nor is it toxic to these cells.
多发性硬化症患者血清中的一种因子可抑制有丝分裂原刺激的活跃代谢淋巴细胞中的RNA、蛋白质和DNA合成。大分子合成的抑制比细胞死亡提前24至36小时。该因子对先前接触有丝分裂原已开始转化的细胞以及同时接触该因子和有丝分裂原的细胞有效。未受刺激的细胞先前接触该因子不会改变其随后对有丝分裂原的反应。该因子不会抑制通过Ficoll-泛影葡胺梯度分离的未受刺激淋巴细胞的RNA合成，对这些细胞也无毒害作用。
