多发性硬化症中抑制细胞对有丝分裂原反应性的调节异常。
Altered regulation of mitogen responsiveness by suppressor cells in multiple sclerosis.
作者信息
Gonzalez R L, Dau P C, Spitler L E
出版信息
Clin Exp Immunol. 1979 Apr;36(1):78-84.
Suppression of the lymphocyte response to concanavalin A (Con A), phytohaemagglutinin (PHA) and protein A from Staphylococcus aureus (SpA) by Con A-induced suppressor cells was measured in twenty-four patients with recently active-recovering multiple sclerosis (MS), twelve with inactive MS and twenty-three healthy controls. Patients with recently active disease displayed significantly greater suppression of the response to Con A. Suppression of the responses to PHA and SpA did not differ among the groups. Lymphocyte stimulation in cultures not showing suppression was similar in all three types of subjects. These results suggest a disturbance of lymphocyte regulation in patients with recently active-recovering MS and illustrate the potential usefulness of measuring the suppression of responsiveness to several mitogens.
在24例近期病情活动-恢复期的多发性硬化症（MS）患者、12例病情静止的MS患者及23名健康对照者中，检测了伴刀豆球蛋白A（Con A）诱导的抑制细胞对刀豆球蛋白A（Con A）、植物血凝素（PHA）和金黄色葡萄球菌A蛋白（SpA）的淋巴细胞反应的抑制作用。近期病情活动的患者对Con A反应的抑制作用显著更强。各组对PHA和SpA反应的抑制作用无差异。在未表现出抑制作用的培养物中，三种类型受试者的淋巴细胞刺激情况相似。这些结果提示近期病情活动-恢复期MS患者存在淋巴细胞调节紊乱，并说明了检测对多种有丝分裂原反应抑制作用的潜在用途。
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