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尽管进行了部分胃切除术,但仍存在铁过载。

Iron overload despite partial gastrectomy.

作者信息

Parfrey P S, Turnbull A L, Pollock D J, Barnett M

出版信息

Postgrad Med J. 1979 Oct;55(648):747-50. doi: 10.1136/pgmj.55.648.747.

Abstract

Iron overload was found in 3 patients who had undergone partial gastrectomy: a 61-year-old woman developed iron overload because she may have had idiopathic haemochromatosis and had also been given parenteral iron; in a 62-year-old man with thalassaemia minor, iron overload may have developed because of increased oral iron ingestion, low serum folate, increased, albeit ineffective, erythropoiesis and sideroblastic anaemia; a 74-year-old man with thalassaemia minor developed iron overload without exogenous therapy and died from a hepatoma. These cases illustrate that partial gastrectomy fails to protect patients from developing iron overload, particularly if given uncontrolled iron therapy.

摘要

在3例接受过胃部分切除术的患者中发现了铁过载:一名61岁女性出现铁过载,可能是因为她患有特发性血色素沉着症且接受过胃肠外铁剂治疗;一名62岁轻度地中海贫血男性出现铁过载,可能是由于口服铁摄入量增加、血清叶酸水平低、红细胞生成增加(尽管无效)以及铁粒幼细胞性贫血;一名74岁轻度地中海贫血男性在未接受外源性治疗的情况下出现铁过载,并死于肝癌。这些病例表明,胃部分切除术不能保护患者免于发生铁过载,特别是在铁剂治疗不受控制的情况下。

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本文引用的文献

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SIDEROBLASTIC ANAEMIA IN MAN: OBSERVATIONS ON SEVENTY CASES.人类铁粒幼细胞性贫血:70例观察报告
Br J Haematol. 1965 Jan;11:59-69. doi: 10.1111/j.1365-2141.1965.tb00085.x.
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IRON ABSORPTION IN THALASSAEMIA.地中海贫血中的铁吸收
Br J Haematol. 1964 Oct;10:490-5. doi: 10.1111/j.1365-2141.1964.tb00726.x.
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Thalassaemia minor complicated by excessive iron storage.轻型地中海贫血合并铁储存过多
Br J Haematol. 1963 Jan;9:13-24. doi: 10.1111/j.1365-2141.1963.tb05436.x.
8
Excessive use of tetanus toxoid boosters.破伤风类毒素加强剂使用过量。
JAMA. 1967 Oct 2;202(1):111-3. doi: 10.1001/jama.202.1.111.

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