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尽管进行了部分胃切除术,但仍存在铁过载。

Iron overload despite partial gastrectomy.

作者信息

Parfrey P S, Turnbull A L, Pollock D J, Barnett M

出版信息

Postgrad Med J. 1979 Oct;55(648):747-50. doi: 10.1136/pgmj.55.648.747.

DOI:10.1136/pgmj.55.648.747
PMID:537965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2425731/
Abstract

Iron overload was found in 3 patients who had undergone partial gastrectomy: a 61-year-old woman developed iron overload because she may have had idiopathic haemochromatosis and had also been given parenteral iron; in a 62-year-old man with thalassaemia minor, iron overload may have developed because of increased oral iron ingestion, low serum folate, increased, albeit ineffective, erythropoiesis and sideroblastic anaemia; a 74-year-old man with thalassaemia minor developed iron overload without exogenous therapy and died from a hepatoma. These cases illustrate that partial gastrectomy fails to protect patients from developing iron overload, particularly if given uncontrolled iron therapy.

摘要

在3例接受过胃部分切除术的患者中发现了铁过载:一名61岁女性出现铁过载,可能是因为她患有特发性血色素沉着症且接受过胃肠外铁剂治疗;一名62岁轻度地中海贫血男性出现铁过载,可能是由于口服铁摄入量增加、血清叶酸水平低、红细胞生成增加(尽管无效)以及铁粒幼细胞性贫血;一名74岁轻度地中海贫血男性在未接受外源性治疗的情况下出现铁过载,并死于肝癌。这些病例表明,胃部分切除术不能保护患者免于发生铁过载,特别是在铁剂治疗不受控制的情况下。

相似文献

1
Iron overload despite partial gastrectomy.尽管进行了部分胃切除术,但仍存在铁过载。
Postgrad Med J. 1979 Oct;55(648):747-50. doi: 10.1136/pgmj.55.648.747.
2
Haemochromatosis in patients with beta-thalassaemia trait.β地中海贫血性状患者的血色素沉着症
Br J Haematol. 2000 Dec;111(3):908-14.
3
Iron overload in beta-thalassaemia minor. A family study.轻型β地中海贫血的铁过载。一项家族研究。
Scand J Haematol. 1981 Oct;27(4):294-302. doi: 10.1111/j.1600-0609.1981.tb00487.x.
4
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Nouv Rev Fr Hematol (1978). 1984;26(5):317-21.
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Gut. 2007 May;56(5):613-4. doi: 10.1136/gut.2006.113076.
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Iron overload across the spectrum of non-transfusion-dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions.非输血依赖型地中海贫血症中的铁过载:红细胞生成、脾切除术及输血的作用
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Cochrane Database Syst Rev. 2012 Feb 15(2):CD007476. doi: 10.1002/14651858.CD007476.pub2.

本文引用的文献

1
Hepatic pathology in relatives of patients with haemochromatosis.血色素沉着症患者亲属的肝脏病理学
J Pathol Bacteriol. 1962 Jul;84:53-64.
2
THE ABSORPTION OF RADIOIRON GIVEN WITH A STANDARD MEAL AFTER POLYA PARTIAL GASTRECTOMY.波利亚部分胃切除术后标准餐食中放射性铁的吸收情况
Clin Sci. 1965 Jun;28:499-509.
3
SIDEROBLASTIC ANAEMIA IN MAN: OBSERVATIONS ON SEVENTY CASES.人类铁粒幼细胞性贫血:70例观察报告
Br J Haematol. 1965 Jan;11:59-69. doi: 10.1111/j.1365-2141.1965.tb00085.x.
4
IRON ABSORPTION IN THALASSAEMIA.地中海贫血中的铁吸收
Br J Haematol. 1964 Oct;10:490-5. doi: 10.1111/j.1365-2141.1964.tb00726.x.
5
METABOLIC EFFECTS OF PARTIAL GASTRECTOMY WITH SPECIAL REFERENCE TO CALCIUM AND FOLIC ACID. II. THE CONTRIBUTION OF FOLIC ACID DEFICIENCY TO THE ANAEMIA.胃部分切除术后的代谢影响,特别涉及钙和叶酸。II. 叶酸缺乏对贫血的影响。
Gut. 1964 Jun;5(3):225-9. doi: 10.1136/gut.5.3.225.
6
Thalassaemia minor complicated by excessive iron storage.轻型地中海贫血合并铁储存过多
Br J Haematol. 1963 Jan;9:13-24. doi: 10.1111/j.1365-2141.1963.tb05436.x.
7
Erythrokinetic studies in thalassemia trait.地中海贫血特征的红细胞动力学研究。
J Lab Clin Med. 1960 Dec;56:866-73.
8
Excessive use of tetanus toxoid boosters.破伤风类毒素加强剂使用过量。
JAMA. 1967 Oct 2;202(1):111-3. doi: 10.1001/jama.202.1.111.
9
Nutritional studies in patients with dumping syndrome. I. Subjects with postcibal symptoms.倾倒综合征患者的营养研究。I. 有食后症状的受试者。
Am J Dig Dis. 1967 Jan;12(1):71-80. doi: 10.1007/BF02235230.
10
Folic acid deficiency and iron overload.叶酸缺乏与铁过载。
Arch Intern Med. 1970 Jan;125(1):140-4.