苯巴比妥对大鼠肝微粒体代谢口服避孕药17α-乙炔雌二醇-3-甲醚（炔雌醇甲醚）的刺激作用。
Stimulatory effect of phenobarbital on the metabolism of the oral contraceptive 17 alpha-ethynylestradiol-3-methyl ether (mestranol) by rat liver microsomes.
作者信息
Levin W, Kuntzman R, Conney A H
出版信息
Pharmacology. 1979;19(5):249-55. doi: 10.1159/000137319.
PMID:538079
Abstract
Pretreatment of rats with phenobarbital for 4 days stimulates the activity of liver microsomal enzymes that metabolize 17 alpha-ethynylestradiol-3-methyl ether (mestranol). This effect provides an explanation for the decreased uterotropic action of mestranol in rats pretreated with phenobarbital and may provide an explanation for unwanted pregnancies in women taking oral contraceptives in combination with phenobarbital or other enzyme-inducing drugs.
摘要
用苯巴比妥预处理大鼠4天，可刺激肝脏微粒体酶的活性，这些酶可代谢17α-乙炔雌二醇-3-甲醚（炔雌醇甲醚）。这种效应解释了在用苯巴比妥预处理的大鼠中炔雌醇甲醚子宫促生长作用的降低，并且可能解释了服用口服避孕药同时服用苯巴比妥或其他酶诱导药物的女性意外怀孕的原因。
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