McDonald R J
Pharmakopsychiatr Neuropsychopharmakol. 1979 Nov;12(6):407-22. doi: 10.1055/s-0028-1094637.
This report reviews 26 clinical drug trials which investigated the effectiveness of Hydergine, a dihydrogenated ergot alkaloid, used frequently in geriatric psychopharmacology. The methodological characteristics and significant results for each study are presented in outline form. In total, 32 symptoms were assessed in six or more studies. Therapeutic benefits following Hydergine treatment occurred in the areas of cognitive dysfunctions, mood depression, and the composite scores as measured by subjective clinical behavioral rating scales. It is suggested that the improvement reported in cognitive functions and mood depression is a reflection of the global change observed by clinicians in patients' overall behavior duirng the interview. This conclusion that Hydergine does produce some global improvement indicates that further research with Hydergine is warranted, provided more objective instruments are employed such as those described in the report.
本报告回顾了26项临床药物试验，这些试验研究了氢化麦角碱（一种二氢麦角生物碱，常用于老年精神药理学）的有效性。每项研究的方法学特征和显著结果以大纲形式呈现。总共在六项或更多研究中评估了32种症状。氢化麦角碱治疗后的治疗益处出现在认知功能障碍、情绪抑郁以及主观临床行为评分量表所测量的综合评分方面。有人认为，认知功能和情绪抑郁方面报告的改善反映了临床医生在访谈期间观察到的患者总体行为的整体变化。氢化麦角碱确实产生了一些整体改善这一结论表明，如果采用更客观的工具（如报告中所述的那些工具），那么对氢化麦角碱进行进一步研究是有必要的。
