碳酸锂对人体昼夜节律的影响。
Effect of lithium carbonate on circadian periodicity in humans.
作者信息
Johnsson A, Pflug B, Engelmann W, Klemke W
出版信息
Pharmakopsychiatr Neuropsychopharmakol. 1979 Nov;12(6):423-5. doi: 10.1055/s-0028-1094638.
PMID:538086
Abstract
Five groups of two volunteers lived during four weeks under arctic summer conditions (Spitsbergen) isolated in huts, without time information. They received lithium carbonate or placebo. All showed free-run of their circadian temperature and activity/rest rhythms with periods longer than 24 hours. Under lithium carbonate, a period-lengthening effect can be shown. This could help to understand theprophylactic effect of lithium salts in manic-depressive episodes.
摘要
五组由两名志愿者组成的小组在北极夏季条件下（斯瓦尔巴群岛），在没有时间信息的小屋里隔离生活了四周。他们服用了碳酸锂或安慰剂。所有人的昼夜体温以及活动/休息节律都呈现出自由运转状态，周期超过24小时。在服用碳酸锂的情况下，可以显示出周期延长的效果。这有助于理解锂盐在躁狂抑郁发作中的预防作用。
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